Gold Trifluoromethyl Complexes as Efficient Regioselective Catalysts in Alkyne Hydration

Ruiz-Almoguera, David ; Ventura-Espinosa, David ; Pérez-Bitrián, Alberto ; Martín, Antonio ; Mata, José A. ; Baya, Miguel (Universidad de Zaragoza)

Resumen: Gold(III) complexes containing trifluoromethyl ligands are efficient catalysts in the hydration of alkynes, operating at low catalyst loadings, without additives, using environmentally friendly solvents and at mild conditions (60 °C). Hydration of terminal and internal alkynes provides the corresponding ketones in quantitative yields without special precautions as dry solvents or inert atmospheres. Remarkably, hydration of asymmetric internal alkynes proceeds with moderate to notable regioselectivities, providing mixtures of the two possible isomers with ratios up to 90 : 10.

Idioma: Inglés

DOI: 10.1002/chem.202401753

Año: 2024

Publicado en: Chemistry - A European Journal 2024, 30 (2024), e202401753 [6 pp.]
ISSN: 0947-6539

Financiación: info:eu-repo/grantAgreement/ES/AEI/PID2021-126071OB-C22
Financiación: info:eu-repo/grantAgreement/ES/DGA/E17-23R
Financiación: info:eu-repo/grantAgreement/ES/MEC/FPU15-03940
Financiación: info:eu-repo/grantAgreement/ES/MICINN/PID2021-122869NB-I00
Financiación: info:eu-repo/grantAgreement/ES/MICINN/RED2022-134074-T
Financiación: info:eu-repo/grantAgreement/ES/MIU/FPU22-02988

Tipo y forma: Article (Published version)

Área (Departamento): Área Química Inorgánica (Dpto. Química Inorgánica)