Advances in Cryopreservatives: Exploring Safer Alternatives

Lomba, Laura ; García, Cristina B. ; Benito, Lucía ; Sangüesa, Estela ; Santander, Sonia (Universidad de Zaragoza) ; Zuriaga, Estefanía

Resumen: Cryopreservation of cells, tissues, and organs is widely used in the biomedical and research world. There are different cryopreservatives that are used for this process; however, many of them, such as DMSO, are used despite the problems they present, mainly due to the toxicity it presents to certain types of samples. The aim of this Review is to highlight the different types of substances used in the cryopreservation process. It has been shown that some of these substances are well-known, as in the case of the families of alcohols, sugars, sulfoxides, etc. However, in recent years, other compounds have appeared, such as ionic liquids, deep eutectic solvents, or certain polymers, which open the door to new cryopreservation methods and are also less toxic to frozen samples.

Idioma: Inglés

DOI: 10.1021/acsbiomaterials.3c00859

Año: 2024

Publicado en: ACS BIOMATERIALS SCIENCE & ENGINEERING 10, 1 (2024), 178-190
ISSN: 2373-9878

Tipo y forma: Artículo (Versión definitiva)

Área (Departamento): Área Farmacología (Dpto. Farmac.Fisiol.y Med.L.F.)