Epigenetic age acceleration in obstructive sleep apnoea is reversible with adherent treatment

Cortese, R. ; Sanz-Rubio, D. ; Kheirandish-Gozal, L. ; Marin, J. M. (Universidad de Zaragoza) ; Gozal, D.

Resumen: Obstructive sleep apnoea (OSA) leads to activation and propagation of oxidative stress and systemic inflammatory pathways, essentially mimicking accelerated biological ageing (senescence). Biological ageing is a complex and time-dependent deterioration of physiological processes with attendant morbidity and mortality. During ageing there is continuous and accelerated accumulation of epigenetic changes manifesting either systemically or restricted to a specific tissue/cell type. Epigenetic clocks, or DNA methylation clocks, have emerged as valuable biological age prediction tools. By regressing DNA methylation age on chronological age, epigenetic clocks can determine whether biological age acceleration occurs in certain diseases or in response to environmental factors. Using this approach, age acceleration measurements in blood were abnormally high in the context of common conditions such as obesity, neurological diseases and cigarette smoking.

Idioma: Inglés

DOI: 10.1183/13993003.03042-2021

Año: 2022

Publicado en: European respiratory journal 59, 4 (2022), 2103042
ISSN: 0903-1936

Factor impacto JCR: 24.9 (2022)

Categ. JCR: RESPIRATORY SYSTEM rank: 2 / 66 = 0.03 (2022) - Q1 - T1

Factor impacto CITESCORE: 25.3 - Medicine (Q1)

Factor impacto SCIMAGO: 4.722 - Pulmonary and Respiratory Medicine (Q1) - Medicine (miscellaneous) (Q1)

Tipo y forma: Article (Published version)

Área (Departamento): Area Medicina (Dpto. Medicina, Psiqu. y Derm.)