The Association Between Major Depression and Alzheimer’s Disease Risk: Evidence from a 12-Year Longitudinal Study

Sevil-Pérez, Anais ; López-Antón, Raúl (Universidad de Zaragoza) ; Gracia-García, Patricia (Universidad de Zaragoza) ; de la Cámara, Concepción (Universidad de Zaragoza) ; Gascón-Catalán, Ana (Universidad de Zaragoza) ; Santabárbara, Javier (Universidad de Zaragoza)

Resumen: Background: The relationship between depression, particularly major depression (MD), as a risk factor for Alzheimer’s disease (AD) is well established; however, its precise role remains contested. Findings from the fourth wave of the ZARADEMP longitudinal study provide further insights into the association between MD and AD risk. Objectives: This study aimed to examine the association between MD and incident AD, controlling for established risk factors. Methods: The study analyzed 4803 participants, of whom 4057 were followed over a 12-year period as part of the ZARADEMP longitudinal study. Depression was assessed using the GMS-AGECAT, and dementia was diagnosed according to DSM-IV criteria. The association between MD and incident AD was evaluated using Cox proportional hazards regression models. Results: The incidence of AD was approximately twice as high in participants with MD compared to those without (relative risk = 2.07; 95% CI: 0.85–5.03; p = 0.123). This risk was nearly threefold higher in the fully adjusted model. Conclusions: These findings underscore a significant association between MD and an increased risk of AD, emphasizing the need for vigilant monitoring and potential early intervention among individuals diagnosed with MD.

Idioma: Inglés

DOI: 10.3390/jcm13237039

Año: 2024

Publicado en: Journal of Clinical Medicine 13, 23 (2024), 7039 [10 pp.]
ISSN: 2077-0383

Financiación: info:eu-repo/grantAgreement/ES/DGA/B15-17R
Financiación: info:eu-repo/grantAgreement/ES/DGA/B15-23R
Financiación: info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/G03-128
Financiación: info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/01-0255
Financiación: info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/03-0815
Financiación: info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/06-0617
Financiación: info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/12-02254
Financiación: info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/16-00896
Financiación: info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/19-01874
Financiación: info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/94-1562
Financiación: info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/97-1321E
Financiación: info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/98-0103

Tipo y forma: Article (Published version)

Área (Departamento): Área Enfermería (Dpto. Fisiatría y Enfermería)
Área (Departamento): Área Psicología Básica (Dpto. Psicología y Sociología)
Área (Departamento): Area Psiquiatría (Dpto. Medicina, Psiqu. y Derm.)
Área (Departamento): Área Medic.Prevent.Salud Públ. (Dpto. Microb.Ped.Radio.Sal.Pú.)