Feed additives for methane mitigation: A guideline to uncover the mode of action of antimethanogenic feed additives for ruminants

Belanche, Alejandro (Universidad de Zaragoza) ; Bannink, André ; Dijkstra, Jan ; Durmic, Zoey ; Garcia, Florencia ; Santos, Fernanda G. ; Huws, Sharon ; Jeyanathan, Jeyamalar ; Lund, Peter ; Mackie, Roderick I. ; McAllister, Tim A. ; Morgavi, Diego P. ; Muetzel, Stefan ; Pitta, Dipti W. ; Yáñez-Ruiz, David R. ; Ungerfeld, Emilio M.

Resumen: This publication aims to provide guidelines of the knowledge required and the potential research to be con-ducted in order to understand the mode of action of anti-methanogenic feed additives (AMFA). In the first part of the paper, we classify AMFA into 4 categories according to their mode of action: (1) lowering dihydrogen (H2) production; (2) inhibiting methanogens; (3) promoting alternative H2-incorporating pathways; and (4) oxidizing methane (CH4). The second part of the paper presents questions that guide the research to identify the mode of action of an AMFA on the rumen CH4 production from 5 different perspectives: (1) microbiology; (2) cell and molecular biochemistry; (3) microbial ecology; (4) animal metabolism; and (5) cross-cutting aspects. Rec-ommendations are provided to address various research questions within each perspective, along with examples of how aspects of the mode of action of AMFA have been elucidated before. In summary, this paper offers timely and comprehensive guidelines to better understand and reveal the mode of action of current and emerging AMFA.

Idioma: Inglés

DOI: 10.3168/jds.2024-25046

Año: 2024

Publicado en: Journal of Dairy Science 108, 1 (2024), 375-394
ISSN: 0022-0302

Financiación: info:eu-repo/grantAgreement/ES/AEI/PID2021-12306OB-I00
Financiación: info:eu-repo/grantAgreement/ES/MICINN/RYC2019-027764-I/AEI/10.13039/501100011033

Tipo y forma: Artículo (Versión definitiva)

Área (Departamento): Área Producción Animal (Dpto. Produc.Animal Cienc.Ali.)