Thermophysical characterization of lidocaine:camphor:thymol or l-menthol eutectic mixtures: Experimental and modelling

Sancho-Blasco, Mónica ; Pastor, Jorge L. ; Muñoz-Embid, José (Universidad de Zaragoza) ; Lafuente, Carlos (Universidad de Zaragoza) ; Artal, Manuela (Universidad de Zaragoza)

Resumen: Knowing the values of the thermodynamic and transport properties of fluids is essential for their implementation in different fields. In addition, their analysis allows us to understand the intermolecular interactions which is useful in the subsequent design of processes. In this work, two ternary eutectic mixtures composed of lidocaine, camphor, and thymol or l-menthol were studied. Six thermophysical properties were measured at 0.1 MPa and at various temperatures. Density values up to 65 MPa were also determined. From these data, different properties were calculated, such as isobaric expansibility, isentropic and isothermal compressibility, internal pressure, and critical temperature, among others. The mixture with thymol was the most dense, structured, and viscous. The correlations and models used showed small deviations between the experimental and estimated values. The deviations of the density and isobaric molar heat capacity predicted with PC-SAFT equation of state were lower than 1.4 % and 3.1 %, respectively. The interactions between lidocaine and thymol were the strongest. On the other hand, camphor was shown to be a steric hindrance to binary interactions.

Idioma: Inglés

DOI: 10.1016/j.molliq.2024.126655

Año: 2025

Publicado en: Journal of Molecular Liquids 417 (2025), 126655 [10 pp.]
ISSN: 0167-7322

Financiación: info:eu-repo/grantAgreement/ES/DGA/E31-23R

Tipo y forma: Artículo (Versión definitiva)

Área (Departamento): Área Química Física (Dpto. Química Física)