Lipid metabolism in overweight/obese children vs. normal weight children in a north-eastern region of Spain
Cuenca Alcocel, José ; Villalba-Heredia, Lorena ; Martínez Redondo, Inés ; Gallego Royo, Alba (Universidad de Zaragoza) ; Casajús, José A. (Universidad de Zaragoza) ; Arbonés-Mainar, José M. ; Calmarza, Pilar
Resumen: Objectives
Obesity and overweight have increased in children and adolescents in Europe in the recent years, accounting for a major global public health problem. The objective of this study was the early detection of metabolic abnormalities in overweight/obese children (8–12 years old) that may ultimately induce impaired glucose metabolism and/or cardiovascular diseases.
Methods
Lipid metabolism and metabolic control parameters were measured and monitored in a group of 61 male and female children with overweight/obesity and a group of 45 healthy, normal weight children, comparing the results obtained. Ages ranged from 8 to 12 years.
Results
Higher levels of triglycerides and insulin and lower levels of high-density lipoprotein (HDL) cholesterol and apolipoprotein A1 were observed in overweight/obese children, as compared to normal weight children. Overweight/obese children exhibited higher apolipoprotein B/apolipoprotein A1 ratio, triglyceride-glucose ratio and HOMA index and a lower low-density lipoprotein (LDL) cholesterol/apolipoprotein B ratio.
Conclusions
Obesity at an early age (8–12 years) negatively affects lipid parameters. Hence, overweight/obese children presented a more atherogenic lipid profile, manifested as higher concentrations of remnant particles and small dense LDL particles, higher insulin resistance and a higher risk for developing diabetes mellitus type 2 and cardiovascular disease, as compared to normal weight children.
Idioma: Inglés
DOI: 10.1515/almed-2025-0015
Año: 2025
Publicado en: Advances in laboratory medicine (2025), [9 pp.]
ISSN: 2628-491X
Tipo y forma: Article (Published version)
Área (Departamento): Área Educación Física y Depor. (Dpto. Fisiatría y Enfermería)
Área (Departamento): Area Medicina (Dpto. Medicina, Psiqu. y Derm.)
You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
Exportado de SIDERAL (2025-10-17-14:25:34)
Visitas y descargas
Obesity and overweight have increased in children and adolescents in Europe in the recent years, accounting for a major global public health problem. The objective of this study was the early detection of metabolic abnormalities in overweight/obese children (8–12 years old) that may ultimately induce impaired glucose metabolism and/or cardiovascular diseases.
Methods
Lipid metabolism and metabolic control parameters were measured and monitored in a group of 61 male and female children with overweight/obesity and a group of 45 healthy, normal weight children, comparing the results obtained. Ages ranged from 8 to 12 years.
Results
Higher levels of triglycerides and insulin and lower levels of high-density lipoprotein (HDL) cholesterol and apolipoprotein A1 were observed in overweight/obese children, as compared to normal weight children. Overweight/obese children exhibited higher apolipoprotein B/apolipoprotein A1 ratio, triglyceride-glucose ratio and HOMA index and a lower low-density lipoprotein (LDL) cholesterol/apolipoprotein B ratio.
Conclusions
Obesity at an early age (8–12 years) negatively affects lipid parameters. Hence, overweight/obese children presented a more atherogenic lipid profile, manifested as higher concentrations of remnant particles and small dense LDL particles, higher insulin resistance and a higher risk for developing diabetes mellitus type 2 and cardiovascular disease, as compared to normal weight children.
Idioma: Inglés
DOI: 10.1515/almed-2025-0015
Año: 2025
Publicado en: Advances in laboratory medicine (2025), [9 pp.]
ISSN: 2628-491X
Tipo y forma: Article (Published version)
Área (Departamento): Área Educación Física y Depor. (Dpto. Fisiatría y Enfermería)
Área (Departamento): Area Medicina (Dpto. Medicina, Psiqu. y Derm.)
You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use. Exportado de SIDERAL (2025-10-17-14:25:34)
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Articles > Artículos por área > Educación Física y Deportiva
Articles > Artículos por área > Medicina
Record created 2025-03-10, last modified 2025-10-17