Biomechanical simulations of crystalline lens oscillations resulting from the changes in the gaze in an accommodated eye
Dahaghin, Ali ; Salimibani, Milad ; Boszczyk, Agnieszka ; Józwik, Agnieszka ; Grasa, Jorge (Universidad de Zaragoza) ; Przezdziecka-Dolyk, Joanna ; Siedlecki, Damian
Resumen: Purpose: The goal of the study is to introduce a generic, versatile biomechanical model that aims to reproduce the dynamic wobbling phenomenon.
Methods: A systematic strategy is used, which includes a) capturing the in vivo data on a group of healthy volunteers, b) analyzing the changes in Purkinje images over time, and c) performing the combined biomechanical and optical simulations to develop the model that might be useful for understanding the mechanical behavior of the lens during wobbling and its influence on ocular dynamics.
Results: Examples of lens wobbling patterns for six measured eyes were presented, and parameters characterizing the oscillatory motion were determined, including frequency of oscillations, Q-factor, damping factor and time constant. The average values of these parameters are the following: frequency: 20.0 ± 2.4 Hz; Q-factor: 1.86 ± 0.44; damping factor: 0.27 ± 0.06; time constant: 0.11 ± 0.06 s. The data reproduced by means of simulations: frequency: 19.3 Hz; Q-factor: 2.17; damping factor: 0.23; time constant: 0.15 s. This comparison reveals a good agreement between the measured and reconstructed data with the values being within the standard deviation limits.
Conclusion: The developed generic model together with the presented methodology is able to reconstruct the typical crystalline lens wobbling dynamics with a satisfying accuracy. However, the observed intersubject variability highlights the need for personalized biomechanical models. The introduced model may constitute the basis for future individualization of the data, bringing broad perspectives for prospective investigations aimed to explain the biomechanical mechanisms within the eye.
Idioma: Inglés
DOI: 10.3389/fbioe.2025.1504769
Año: 2025
Publicado en: Frontiers in Bioengineering and Biotechnology 13 (2025), 1504769 [11 pp.]
ISSN: 2296-4185
Financiación: info:eu-repo/grantAgreement/EC/H2020/956720/EU/Opto-Biomechanical Eye Research Network/OBERON
Tipo y forma: Artículo (Versión definitiva)
Área (Departamento): Área Mec.Med.Cont. y Teor.Est. (Dpto. Ingeniería Mecánica)
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Methods: A systematic strategy is used, which includes a) capturing the in vivo data on a group of healthy volunteers, b) analyzing the changes in Purkinje images over time, and c) performing the combined biomechanical and optical simulations to develop the model that might be useful for understanding the mechanical behavior of the lens during wobbling and its influence on ocular dynamics.
Results: Examples of lens wobbling patterns for six measured eyes were presented, and parameters characterizing the oscillatory motion were determined, including frequency of oscillations, Q-factor, damping factor and time constant. The average values of these parameters are the following: frequency: 20.0 ± 2.4 Hz; Q-factor: 1.86 ± 0.44; damping factor: 0.27 ± 0.06; time constant: 0.11 ± 0.06 s. The data reproduced by means of simulations: frequency: 19.3 Hz; Q-factor: 2.17; damping factor: 0.23; time constant: 0.15 s. This comparison reveals a good agreement between the measured and reconstructed data with the values being within the standard deviation limits.
Conclusion: The developed generic model together with the presented methodology is able to reconstruct the typical crystalline lens wobbling dynamics with a satisfying accuracy. However, the observed intersubject variability highlights the need for personalized biomechanical models. The introduced model may constitute the basis for future individualization of the data, bringing broad perspectives for prospective investigations aimed to explain the biomechanical mechanisms within the eye.
Idioma: Inglés
DOI: 10.3389/fbioe.2025.1504769
Año: 2025
Publicado en: Frontiers in Bioengineering and Biotechnology 13 (2025), 1504769 [11 pp.]
ISSN: 2296-4185
Financiación: info:eu-repo/grantAgreement/EC/H2020/956720/EU/Opto-Biomechanical Eye Research Network/OBERON
Tipo y forma: Artículo (Versión definitiva)
Área (Departamento): Área Mec.Med.Cont. y Teor.Est. (Dpto. Ingeniería Mecánica)
Debe reconocer adecuadamente la autoría, proporcionar un enlace a la licencia e indicar si se han realizado cambios. Puede hacerlo de cualquier manera razonable, pero no de una manera que sugiera que tiene el apoyo del licenciador o lo recibe por el uso que hace. Exportado de SIDERAL (2025-10-17-14:36:38)
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Este artículo se encuentra en las siguientes colecciones:
Artículos > Artículos por área > Mec. de Medios Contínuos y Teor. de Estructuras
Registro creado el 2025-04-03, última modificación el 2025-10-17