Using Genomics to Develop Personalized Cardiovascular Treatments

Sanghvi, Mihir M. ; Young, William J. ; Naderi, Hafiz ; Burns, Richard ; Ramírez, Julia (Universidad de Zaragoza) ; Bell, Christopher G. ; Munroe, Patricia B.

Resumen: Advances in genomic technologies have significantly enhanced our understanding of both monogenic and polygenic etiologies of cardiovascular disease. In this review, we explore how the utilization of genomic information is bringing personalized medicine approaches to the forefront of cardiovascular disease management. We describe how genomic data can resolve diagnostic uncertainty, support cascade screening, and inform treatment strategies. We discuss how genome-wide association studies have identified thousands of genetic variants associated with polygenic cardiovascular diseases, and how integrating these insights into polygenic risk scores can enhance personalized risk prediction beyond traditional clinical algorithms. We detail how pharmacogenomics approaches leverage genotype information to guide drug selection and mitigate adverse events. Finally, we present the paradigm-shifting approach of gene therapy, which holds the promise of being a curative intervention for cardiovascular conditions.

Idioma: Inglés

DOI: 10.1161/ATVBAHA.125.319221

Año: 2025

Publicado en: Arteriosclerosis, Thrombosis, and Vascular Biology 45, 6 (2025), 866-881
ISSN: 1079-5642

Financiación: info:eu-repo/grantAgreement/ES/AEI/PID2021-128972OA-I00
Financiación: info:eu-repo/grantAgreement/ES/AEI/PID2023-148975OB-I00
Financiación: info:eu-repo/grantAgreement/ES/MICINN/CNS2023-143599
Financiación: info:eu-repo/grantAgreement/ES/MICINN/RYC2021-031413-I

Tipo y forma: Article (PostPrint)

Área (Departamento): Área Teoría Señal y Comunicac. (Dpto. Ingeniería Electrón.Com.)