Magnetic hyperthermia drastically enhances killing of Mycobacterium tuberculosis by bacteriocin AS-48 grafted on biomimetic nanoparticles
Jimenez-Carretero, Monica ; Gómez, Ana Belén (Universidad de Zaragoza) ; Lázaro, Marina ; Millán-Placer, Ana Cristina ; Gaglio, Salvatore C. ; Anoz-Carbonell, Ernesto ; Picó, Ana (Universidad de Zaragoza) ; Baranyai, Zsuzsa ; Jabalera, Ylenia ; Maqueda, Mercedes ; Carrasco-Jiménez, María Paz ; Perduca, Massimiliano ; de la Fuente, Jesús M. ; Iglesias, Guillermo R. ; Montalbán-López, Manuel ; Jimenez-Lopez, Concepcion ; Aínsa, José A. (Universidad de Zaragoza)
Resumen: Mycobacterium tuberculosis, the etiological agent of human tuberculosis, is an intracellular pathogen responsible for one of the infectious diseases with highest mortality rates. Its ability to replicate inside alveolar macrophages and trigger the formation of granulomas, alongside the appearance of multidrug-resistant strains, impose the employment of drugs that exacerbate their toxic effects after the long therapies necessary to deal with the infection. As an alternative to conventional drugs, this work proposes the use of bacteriocin AS-48 immobilized on biomimetic magnetic nanoparticles (BMNPs) as a nanoformulation capable of killing M. tuberculosis in infected THP-1 macrophages, which allows combination with magnetic hyperthermia to increase its effectiveness. This work is a proof of concept of a nanosystem that could potentially be magnetically directed to infected areas, where it could be applied locally. Our results show that AS-48_BMNP nanoassemblies used against M. tuberculosis in vitro display a synergistic effect with magnetic hyperthermia that can completely eradicate the bacteria from infected macrophages in four days. This combined treatment represents a promising opportunity for the future development of a local therapy for the treatment of M. tuberculosis.
Idioma: Inglés
DOI: 10.1016/j.ijbiomac.2025.145441
Año: 2025
Publicado en: International journal of biological macromolecules 319, Part 2 (2025), 145441 [10 pp.]
ISSN: 0141-8130
Financiación: info:eu-repo/grantAgreement/ES/ISCIII/PI20-01658
Financiación: info:eu-repo/grantAgreement/ES/MINECO/EQC2019-005930-P
Financiación: info:eu-repo/grantAgreement/ES/MINECO/PDC2021-121135-I00
Tipo y forma: Article (Published version)
Área (Departamento): Área Microbiología (Dpto. Microb.Ped.Radio.Sal.Pú.)
Área (Departamento): Proy. investigación HQA (Dpto. Microb.Ped.Radio.Sal.Pú.)
You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use. You may not use the material for commercial purposes.
Exportado de SIDERAL (2025-10-17-14:20:47)
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Idioma: Inglés
DOI: 10.1016/j.ijbiomac.2025.145441
Año: 2025
Publicado en: International journal of biological macromolecules 319, Part 2 (2025), 145441 [10 pp.]
ISSN: 0141-8130
Financiación: info:eu-repo/grantAgreement/ES/ISCIII/PI20-01658
Financiación: info:eu-repo/grantAgreement/ES/MINECO/EQC2019-005930-P
Financiación: info:eu-repo/grantAgreement/ES/MINECO/PDC2021-121135-I00
Tipo y forma: Article (Published version)
Área (Departamento): Área Microbiología (Dpto. Microb.Ped.Radio.Sal.Pú.)
Área (Departamento): Proy. investigación HQA (Dpto. Microb.Ped.Radio.Sal.Pú.)
You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use. You may not use the material for commercial purposes. Exportado de SIDERAL (2025-10-17-14:20:47)
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Record created 2025-07-10, last modified 2025-10-17