Heart Rate Profiles During Exercise and Incident Parkinson's Disease
van Duijvenboden, Stefan ; Ramírez, Julia (Universidad de Zaragoza) ; Scheurink, Job ; Darweesh, Sirwan K. L. ; Orini, Michele ; Tinker, Andrew ; Munroe, Patricia B. ; Thannhauser, Jos ; Evers, Luc ; IntHout, Joanna ; Lambiase, Pier D. ; Bloem, Bastiaan R. ; Doherty, Aiden ; Brouwer, Marc A.
Resumen: Objective: To determine whether established heart rate parameters of exercise, related to cardiac autonomic function, are associated with incident Parkinson’s disease, independent of both clinical and autonomic prodromal features.
Methods: A study of UK Biobank participants who performed a standardized bicycle exercise test (2009–2013), followed until November 2022, and analyzed in January 2024, was carried out. Heart rate increase from rest to exer-
cise, and heart rate decrease from peak exercise to recovery were associated with incident Parkinson’s disease. Multivariable adjustment was performed both for clinical characteristics and for prodromal non-cardiac autonomic features.
Results: A total of 69,288 eligible participants (men 48%, mean age 56.8 years [SD 8.2 years]) were followed for 12.5 years: among the 319 (0.5%) who developed Parkinson’s disease, recognized prodromal markers (constipation, bladder dysfunction) were more common at baseline. The median lag time to diagnosis was 9.3 years (interquartile range 4.4). Both heart rate increase (37.5 [SD 11.5] vs 40.8 [SD 12.4] b.p.m., p < 0.001) and recovery (23.4 [SD 8.8] vs. 27.8 [SD 10.3] b.p.m., p < 0.001) were significantly lower in incident cases compared with controls. Heart rate recovery was independently associated with incident Parkinson’s disease, whereas heart rate increase was not. Specifically, a blunted heart rate lowering during recovery was associated with a 30% higher risk of incident Parkinson’s disease (HR 1.3; 95% CI 1.1–1.4; p < 0.001 per 10 beats less recovery).
Interpretation: Collectively, this suggests that cardiac autonomic involvement precedes clinically manifest Parkinson’s disease, and that heart rate recovery might serve as a quantitative prodromal marker.
Idioma: Inglés
DOI: 10.1002/ana.70010
Año: 2025
Publicado en: ANNALS OF NEUROLOGY (2025), [10 pp.]
ISSN: 0364-5134
Tipo y forma: Article (Published version)
Área (Departamento): Área Teoría Señal y Comunicac. (Dpto. Ingeniería Electrón.Com.)
You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
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Methods: A study of UK Biobank participants who performed a standardized bicycle exercise test (2009–2013), followed until November 2022, and analyzed in January 2024, was carried out. Heart rate increase from rest to exer-
cise, and heart rate decrease from peak exercise to recovery were associated with incident Parkinson’s disease. Multivariable adjustment was performed both for clinical characteristics and for prodromal non-cardiac autonomic features.
Results: A total of 69,288 eligible participants (men 48%, mean age 56.8 years [SD 8.2 years]) were followed for 12.5 years: among the 319 (0.5%) who developed Parkinson’s disease, recognized prodromal markers (constipation, bladder dysfunction) were more common at baseline. The median lag time to diagnosis was 9.3 years (interquartile range 4.4). Both heart rate increase (37.5 [SD 11.5] vs 40.8 [SD 12.4] b.p.m., p < 0.001) and recovery (23.4 [SD 8.8] vs. 27.8 [SD 10.3] b.p.m., p < 0.001) were significantly lower in incident cases compared with controls. Heart rate recovery was independently associated with incident Parkinson’s disease, whereas heart rate increase was not. Specifically, a blunted heart rate lowering during recovery was associated with a 30% higher risk of incident Parkinson’s disease (HR 1.3; 95% CI 1.1–1.4; p < 0.001 per 10 beats less recovery).
Interpretation: Collectively, this suggests that cardiac autonomic involvement precedes clinically manifest Parkinson’s disease, and that heart rate recovery might serve as a quantitative prodromal marker.
Idioma: Inglés
DOI: 10.1002/ana.70010
Año: 2025
Publicado en: ANNALS OF NEUROLOGY (2025), [10 pp.]
ISSN: 0364-5134
Tipo y forma: Article (Published version)
Área (Departamento): Área Teoría Señal y Comunicac. (Dpto. Ingeniería Electrón.Com.)
You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use. Exportado de SIDERAL (2025-10-17-14:18:24)
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Record created 2025-09-19, last modified 2025-10-17