Optical fiber integration in PDMS devices for dynamic tissue deformation

Velarte, Antonio (Universidad de Zaragoza) ; Sannino, Andrea (Universidad de Zaragoza) ; Otin, Aranzazu (Universidad de Zaragoza) ; Santamaría, Beatriz ; Artigas, José Ignacio (Universidad de Zaragoza) ; Pueyo, Esther (Universidad de Zaragoza)

Resumen: This study introduces an advanced optical fiber-based stretchable sensing platform designed for precise biomechanical characterization in tissue engineering applications, specifically tailored for cardiac tissue studies. The system is entirely fabricated from biocompatible polydimethylsiloxane (PDMS) material, and features a thin upper membrane and an internal cavity where controlled pneumatic deformation occurs. Deformation is quantified through changes in optical intensity measured through a strategically aligned optical fiber pair, as membrane stretching disrupts total internal reflection conditions. Finite element modeling using COMSOL is used to optimize device geometry and predict deformation, which is subsequently validated through experimental analyses. A custom-designed electronic system with capacity for real-time signal processing ensures stable and sensitive data acquisition. The experimental results show high levels of linearity and repeatability in a physiologically relevant stretch range, highlighting its potential for biomechanical research applications and dynamic tissue stimulation. Future improvements are directed toward extending the reliable deformation operating range through advances in the optical system.

Idioma: Inglés

DOI: 10.1016/j.rineng.2025.107376

Año: 2025

Publicado en: Results in Engineering 28 (2025), 107376 [10 pp.]
ISSN: 2590-1230

Financiación: info:eu-repo/grantAgreement/ES/DGA/GEPM T23-23
Financiación: info:eu-repo/grantAgreement/ES/DGA/LMP94_21
Financiación: info:eu-repo/grantAgreement/ES/DGA/T39-23R
Financiación: info:eu-repo/grantAgreement/ES/ISCIII/PT23-00167
Financiación: info:eu-repo/grantAgreement/ES/MICINN/PID2022-140556OB-I00
Financiación: info:eu-repo/grantAgreement/ES/MICINN/PID2023-149403NB-I00
Financiación: info:eu-repo/grantAgreement/EUR/MICINN/TED2021-130459B-I00

Tipo y forma: Artículo (Versión definitiva)

Área (Departamento): Área Tecnología Electrónica (Dpto. Ingeniería Electrón.Com.)
Área (Departamento): Área Teoría Señal y Comunicac. (Dpto. Ingeniería Electrón.Com.)