Editorial: Mitochondrial OXPHOS System: Emerging Concepts and Technologies and Role in Disease

Fernández-Vizarra, Erika ; Callegari, Sylvie ; Garrabou, Gloria ; Pacheu-Grau, David (Universidad de Zaragoza)

Resumen: Mitochondria are eukaryotic organelles responsible for generating the main bulk of ATP, the cellular energy currency, via the process of oxidative phosphorylation (OXPHOS). The OXPHOS system is unique because it comprises subunits of dual genetic origin, encoded in the mitochondrial and the nuclear genomes. Therefore, to form the multimeric membrane-bound complexes responsible for this energy production process, proteins translated inside the organelle must be assembled in coordination with those expressed in the cytosol and imported into mitochondria by using a sophisticated import and translocation machinery. The idea that the OXPHOS system plays a role not only in ATP production but also in regulating many physiological and pathological processes has been emerging for more than 10 years. Recent evidence points to the existence of intricate quality control systems that guarantee the functionality of mitochondria, as well as the interactions of intramitochondrial and extramitochondrial factors that ultimately influence mitochondrial bioenergetics. For these reasons this Research Topic is a timely release, covering emerging concepts relating to the structure, function, and regulation of the OXPHOS system. In addition, the Research Topic also presents novel technological approaches to unravel the yet unknown intricacies involving this group of protein complexes as well as new mechanisms or pathways linking OXPHOS dysfunction and pathological states.

Idioma: Inglés

DOI: 10.3389/fcell.2022.924272

Año: 2022

Publicado en: Frontiers in Cell and Developmental Biology 10 (2022), 924272 [3 pp.]
ISSN: 2296-634X

Factor impacto JCR: 5.5 (2022)

Categ. JCR: DEVELOPMENTAL BIOLOGY rank: 5 / 39 = 0.128 (2022) - Q1 - T1
Categ. JCR: CELL BIOLOGY rank: 66 / 191 = 0.346 (2022) - Q2 - T2

Factor impacto CITESCORE: 6.3 - Biochemistry, Genetics and Molecular Biology (Q2)

Factor impacto SCIMAGO: 1.418 - Developmental Biology (Q1) - Cell Biology (Q2)

Tipo y forma: (Published version)

Área (Departamento): Área Bioquímica y Biolog.Mole. (Dpto. Bioq.Biolog.Mol. Celular)