Gut microbiota composition and derived enterotypes are associated with ponderal status in preschool children. Childhood obesity risk assessment longitudinal study (CORALS) cohort
Vázquez-Bolea, Natalia ; Mora-Martínez, Carlos ; Cuervo, Marta ; Martinez, J. Alfredo ; Gil-Campos, Mercedes ; Leis, Rosaura ; Babio, Nancy ; Moreno, Luis A. ; Corella, Dolores ; Moreira Echeverria, Ana ; Aguilera, Concepcion M. ; Castro-Collado, Cristina ; Picáns-Leis, Rosaura ; Hernández-Cacho, Adrián ; Miguel-Berges, Maria L. ; Martin-Climent, Paula ; Jurado-Castro, Jose Manuel ; Vázquez-Cobela, Rocío ; Plaza-Diaz, Julio ; Rueda-De Torre, Isabel (Universidad de Zaragoza) ; Pastor-Villaescusa, Belén ; de la Torre-Aguilar, Maria José ; Salas-Salvadó, Jordi ; Sanz, Yolanda ; Navas-Carretero, Santiago
Resumen: Summary
Background and aims
Childhood obesity is a growing public health concern increasingly linked to gut microbiota. We analysed associations between microbiota composition, functionality, and weight status in 1134 children aged 3–6 years from the CORALS cohort.
Methods
The baseline cross-sectional study stratified participants by weight status (underweight, normal weight, overweight, obesity) and performed shotgun metagenomic sequencing of stool samples. Analyses in R assessed alpha/beta diversity, taxonomic composition, enterotypes, and microbial pathways.
Results
Alpha diversity decreased with increasing BMI, particularly in obesity (Shannon adj.P = 0.00301; Simpson adj.P = 0.00158). Beta diversity revealed distinct microbial structures across groups (p = 0.001). Four enterotypes were identified: obesity was associated with Enterotype 3 (Segatella-dominated, p = 0.023), while Enterotype 1 (Alistipes, Akkermansia, Coprococcus) was enriched in underweight/normal weight. Species linked to obesity included higher Phocaeicola dorei (adj.P = 0.003) and Segatella hominis (adj.P = 0.001), and lower Longicatena caecimuris (adj.P = 0.03) and Blautia parvula (adj.P = 0.003). Functional analyses showed downregulation of vitamin and nucleotide biosynthesis pathways and reduced carbohydrate metabolism in overweight/obesity.
Conclusions
Gut microbiota composition and functionality are strongly associated with weight status in early childhood, suggesting microbial biomarkers and metabolic pathways relevant to understand early obesity development.
Idioma: Inglés
DOI: 10.1016/j.clnu.2025.106558
Año: 2025
Publicado en: Clinical Nutrition 57 (2025), 106558 [14 pp.]
ISSN: 0261-5614
Financiación: info:eu-repo/grantAgreement/ES/MICINN/CEX2021-001189-S
Financiación: info:eu-repo/grantAgreement/EUR/MICINN/PID2023-150693OB
Tipo y forma: Article (Published version)
Área (Departamento): Área Medic.Prevent.Salud Públ. (Dpto. Microb.Ped.Radio.Sal.Pú.)
You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use. You may not use the material for commercial purposes. If you remix, transform, or build upon the material, you may not distribute the modified material.
Exportado de SIDERAL (2026-03-01-17:54:17)
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Background and aims
Childhood obesity is a growing public health concern increasingly linked to gut microbiota. We analysed associations between microbiota composition, functionality, and weight status in 1134 children aged 3–6 years from the CORALS cohort.
Methods
The baseline cross-sectional study stratified participants by weight status (underweight, normal weight, overweight, obesity) and performed shotgun metagenomic sequencing of stool samples. Analyses in R assessed alpha/beta diversity, taxonomic composition, enterotypes, and microbial pathways.
Results
Alpha diversity decreased with increasing BMI, particularly in obesity (Shannon adj.P = 0.00301; Simpson adj.P = 0.00158). Beta diversity revealed distinct microbial structures across groups (p = 0.001). Four enterotypes were identified: obesity was associated with Enterotype 3 (Segatella-dominated, p = 0.023), while Enterotype 1 (Alistipes, Akkermansia, Coprococcus) was enriched in underweight/normal weight. Species linked to obesity included higher Phocaeicola dorei (adj.P = 0.003) and Segatella hominis (adj.P = 0.001), and lower Longicatena caecimuris (adj.P = 0.03) and Blautia parvula (adj.P = 0.003). Functional analyses showed downregulation of vitamin and nucleotide biosynthesis pathways and reduced carbohydrate metabolism in overweight/obesity.
Conclusions
Gut microbiota composition and functionality are strongly associated with weight status in early childhood, suggesting microbial biomarkers and metabolic pathways relevant to understand early obesity development.
Idioma: Inglés
DOI: 10.1016/j.clnu.2025.106558
Año: 2025
Publicado en: Clinical Nutrition 57 (2025), 106558 [14 pp.]
ISSN: 0261-5614
Financiación: info:eu-repo/grantAgreement/ES/MICINN/CEX2021-001189-S
Financiación: info:eu-repo/grantAgreement/EUR/MICINN/PID2023-150693OB
Tipo y forma: Article (Published version)
Área (Departamento): Área Medic.Prevent.Salud Públ. (Dpto. Microb.Ped.Radio.Sal.Pú.)
You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use. You may not use the material for commercial purposes. If you remix, transform, or build upon the material, you may not distribute the modified material. Exportado de SIDERAL (2026-03-01-17:54:17)
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Record created 2026-03-01, last modified 2026-03-01