Effects of non-pharmacological interventions on inflammatory biomarker expression in patients with fibromyalgia: A systematic review
Resumen: Introduction: Fibromyalgia (FM) is a prevalent disorder. However, few studies have evaluated the effect of treatment interventions on biomarker expression. The aim of this review was to explore the efficacy of non-pharmacological interventions on inflammatory biomarker expression, specifically cytokines, neuropeptides and C-reactive protein (CRP), in FM patients. Method: A literature search using PubMed, EMBASE, PsycINFO and the Cochrane library was performed from January 1990 to March 2015. Randomized controlled trials (RCTs) and non-RCTs published in English, French or Spanish were eligible. Results: Twelve articles with a total of 536 participants were included. After exercise, multidisciplinary, or dietary interventions in FM patients, interleukin (IL) expression appeared reduced, specifically serum IL-8 and IL-6 (spontaneous, lipopolysaccharide (LPS)-induced, or serum). Furthermore, the changes to insulin-like growth factor 1 (IGF-1) levels might indicate a beneficial role for fatigue in obese FM patients. In contrast, evidence of changes in neuropeptide and CRP levels seemed inconsistent. Conclusion: Despite minimal evidence, our findings indicate that exercise interventions might act as an anti-inflammatory treatment in FM patients and ameliorate inflammatory status, especially for pro-inflammatory cytokines. Additional RCTs focused on the changes to inflammatory biomarker expression after non-pharmacological interventions in FM patients are needed.
Idioma: Inglés
DOI: 10.1186/s13075-015-0789-9
Año: 2015
Publicado en: ARTHRITIS RESEARCH & THERAPY 17, 272 (2015), [16 pp.]
ISSN: 1478-6354

Factor impacto JCR: 3.979 (2015)
Categ. JCR: RHEUMATOLOGY rank: 8 / 31 = 0.258 (2015) - Q2 - T1
Factor impacto SCIMAGO: 1.955 - Immunology (Q1) - Rheumatology (Q1) - Immunology and Allergy (Q1)

Financiación: info:eu-repo/grantAgreement/ES/MICINN/ISCIII-RD06-0018-0017
Financiación: info:eu-repo/grantAgreement/ES/MINECO/PSI2014-56303-REDT
Tipo y forma: Artículo (Versión definitiva)
Área (Departamento): Area Psiquiatría (Dpto. Medicina, Psiqu. y Derm.)
Área (Departamento): Área Person.Eval.Trat.Psicoló. (Dpto. Psicología y Sociología)


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