Fibroblast migration in 3D is controlled by haptotaxis in a non-muscle myosin II-dependent manner
Moreno-Arotzena, O. ; Borau, C. (Universidad de Zaragoza) ; Movilla, N. ; Vicente-Manzanares, M. ; García-Aznar, J.M. (Universidad de Zaragoza)
Resumen: Cell migration in 3D is a key process in many physiological and pathological processes. Although valuable knowledge has been accumulated through analysis of various 2D models, some of these insights are not directly applicable to migration in 3D. In this study, we have confined biomimetic hydrogels within microfluidic platforms in the presence of a chemoattractant (platelet-derived growth fac- tor-BB). We have characterized the migratory responses of human fibroblasts within them, particularly focusing on the role of non-muscle myosin II. Our results indicate a prominent role for myosin II in the integration of chemo- tactic and haptotactic migratory responses of fibroblasts in 3D confined environments.
Idioma: Inglés
DOI: 10.1007/s10439-015-1343-2
Año: 2015
Publicado en: Annals of Biomedical Engineering 43, 12 (2015), 3025-3039
ISSN: 0090-6964
Factor impacto JCR: 2.887 (2015)
Categ. JCR: ENGINEERING, BIOMEDICAL rank: 16 / 76 = 0.211 (2015) - Q1 - T1
Factor impacto SCIMAGO: 1.2 - Biomedical Engineering (Q1)
Financiación: info:eu-repo/grantAgreement/EUR/FP7/ERC2012-StG-306751
Financiación: info:eu-repo/grantAgreement/ES/MINECO/DPI2012-38090-C03-01
Financiación: info:eu-repo/grantAgreement/ES/MINECO/SAF2011-24953
Tipo y forma: Article (Published version)
Área (Departamento): Área Mec.Med.Cont. y Teor.Est. (Dpto. Ingeniería Mecánica)
You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use. You may not use the material for commercial purposes. If you remix, transform, or build upon the material, you may not distribute the modified material.
Exportado de SIDERAL (2021-01-21-08:17:39)
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Idioma: Inglés
DOI: 10.1007/s10439-015-1343-2
Año: 2015
Publicado en: Annals of Biomedical Engineering 43, 12 (2015), 3025-3039
ISSN: 0090-6964
Factor impacto JCR: 2.887 (2015)
Categ. JCR: ENGINEERING, BIOMEDICAL rank: 16 / 76 = 0.211 (2015) - Q1 - T1
Factor impacto SCIMAGO: 1.2 - Biomedical Engineering (Q1)
Financiación: info:eu-repo/grantAgreement/EUR/FP7/ERC2012-StG-306751
Financiación: info:eu-repo/grantAgreement/ES/MINECO/DPI2012-38090-C03-01
Financiación: info:eu-repo/grantAgreement/ES/MINECO/SAF2011-24953
Tipo y forma: Article (Published version)
Área (Departamento): Área Mec.Med.Cont. y Teor.Est. (Dpto. Ingeniería Mecánica)
You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use. You may not use the material for commercial purposes. If you remix, transform, or build upon the material, you may not distribute the modified material. Exportado de SIDERAL (2021-01-21-08:17:39)
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Este artículo se encuentra en las siguientes colecciones:
Articles > Artículos por área > Mec. de Medios Contínuos y Teor. de Estructuras
Record created 2015-11-05, last modified 2021-01-21