Home > Articles > Genetic variants in the PPARD-PPARGC1A-NRF-TFAM mitochondriogenesis pathway are neither associated with muscle characteristics nor physical performance in elderly
Resumen: We studied the influence of genetic polymorphisms involved in the PPARD-PPARGC1A-NRF-TFAM mitochondriogenesis pathway (rs6949152, rs12594956, rs2267668, rs8192678, and rs1937) on muscle phenotypes (thigh muscles’ cross-sectional, maximal handgrip-strength and 30-second chair stand-test) and Barthel index in Caucasian (Spanish) community-dwelling old people (n=75, 21 men, 54 women; 71–94 years). We found no significant genetic associations with the studied phenotypes. Multiple, com- plex gene-environment and gene-gene interactions which are yet to be determined are likely to play a more determinant role. Idioma: Inglés DOI: 10.5232/ricyde2015.04101 Año: 2015 Publicado en: Revista internacional de ciencias del deporte 11, 41 (2015), 196-208 ISSN: 1885-3137 Factor impacto SCIMAGO: 0.244 - Physical Therapy, Sports Therapy and Rehabilitation (Q3) - Sports Science (Q4)