Genetic variants in the PPARD-PPARGC1A-NRF-TFAM mitochondriogenesis pathway are neither associated with muscle characteristics nor physical performance in elderly
Garatachea-Vallejo, N. (Universidad de Zaragoza) ; Santiago, C. ; Yvert, T. ; Verde-Rello, Z. ; Fiuza-Luces, C. ; Santos-Lozano, A. ; Gómez-Gallego, F. ; Lucía, A.
Resumen: We studied the influence of genetic polymorphisms involved in the PPARD-PPARGC1A-NRF-TFAM mitochondriogenesis pathway (rs6949152, rs12594956, rs2267668, rs8192678, and rs1937) on muscle phenotypes (thigh muscles’ cross-sectional, maximal handgrip-strength and 30-second chair stand-test) and Barthel index in Caucasian (Spanish) community-dwelling old people (n=75, 21 men, 54 women; 71–94 years). We found no significant genetic associations with the studied phenotypes. Multiple, com- plex gene-environment and gene-gene interactions which are yet to be determined are likely to play a more determinant role.
Idioma: Inglés
DOI: 10.5232/ricyde2015.04101
Año: 2015
Publicado en: Revista internacional de ciencias del deporte 11, 41 (2015), 196-208
ISSN: 1885-3137
Factor impacto SCIMAGO: 0.244 - Physical Therapy, Sports Therapy and Rehabilitation (Q3) - Sports Science (Q4)
Financiación: info:eu-repo/grantAgreement/ES/MINECO/FIS/PI09-00194
Tipo y forma: Article (Published version)
Área (Departamento): Área Educación Física y Depor. (Dpto. Fisiatría y Enfermería)
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Idioma: Inglés
DOI: 10.5232/ricyde2015.04101
Año: 2015
Publicado en: Revista internacional de ciencias del deporte 11, 41 (2015), 196-208
ISSN: 1885-3137
Factor impacto SCIMAGO: 0.244 - Physical Therapy, Sports Therapy and Rehabilitation (Q3) - Sports Science (Q4)
Financiación: info:eu-repo/grantAgreement/ES/MINECO/FIS/PI09-00194
Tipo y forma: Article (Published version)
Área (Departamento): Área Educación Física y Depor. (Dpto. Fisiatría y Enfermería)
You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use. You may not use the material for commercial purposes. If you remix, transform, or build upon the material, you may not distribute the modified material. Exportado de SIDERAL (2021-01-21-10:48:23)
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Record created 2016-03-10, last modified 2021-01-21