Genetic variants in the PPARD-PPARGC1A-NRF-TFAM mitochondriogenesis pathway are neither associated with muscle characteristics nor physical performance in elderly

Garatachea-Vallejo, N. (Universidad de Zaragoza) ; Santiago, C. ; Yvert, T. ; Verde-Rello, Z. ; Fiuza-Luces, C. ; Santos-Lozano, A. ; Gómez-Gallego, F. ; Lucía, A.

Resumen: We studied the influence of genetic polymorphisms involved in the PPARD-PPARGC1A-NRF-TFAM mitochondriogenesis pathway (rs6949152, rs12594956, rs2267668, rs8192678, and rs1937) on muscle phenotypes (thigh muscles’ cross-sectional, maximal handgrip-strength and 30-second chair stand-test) and Barthel index in Caucasian (Spanish) community-dwelling old people (n=75, 21 men, 54 women; 71–94 years). We found no significant genetic associations with the studied phenotypes. Multiple, com- plex gene-environment and gene-gene interactions which are yet to be determined are likely to play a more determinant role.

Idioma: Inglés

DOI: 10.5232/ricyde2015.04101

Año: 2015

Publicado en: Revista internacional de ciencias del deporte 11, 41 (2015), 196-208
ISSN: 1885-3137

Factor impacto SCIMAGO: 0.244 - Physical Therapy, Sports Therapy and Rehabilitation (Q3) - Sports Science (Q4)

Financiación: info:eu-repo/grantAgreement/ES/MINECO/FIS/PI09-00194

Tipo y forma: Article (Published version)

Área (Departamento): Área Educación Física y Depor. (Dpto. Fisiatría y Enfermería)