Mannose receptor may be involved in small ruminant lentivirus pathogenesis

Crespo, H. ; Jauregui, P. ; Glaria, I. ; Sanjosé, L. ; Polledo, L. ; García-Marín, J.F. ; Luján, L. (Universidad de Zaragoza) ; De Andrés, D. ; Amorena, B. ; Reina, R.

Resumen: Thirty-one sheep naturally infected with small ruminant lentiviruses (SRLV) of known genotype (A or B), and clinically affected with neurological disease, pneumonia or arthritis were used to analyse mannose receptor (MR) expression (transcript levels) and proviral load in virus target tissues (lung, mammary gland, CNS and carpal joints). Control sheep were SRLV-seropositive asymptomatic (n¿=¿3), seronegative (n¿=¿3) or with chronic listeriosis, pseudotuberculosis or parasitic cysts (n¿=¿1 in each case). MR expression and proviral load increased with the severity of lesions in most analyzed organs of the SRLV infected sheep and was detected in the affected tissue involved in the corresponding clinical disease (CNS, lung and carpal joint in neurological disease, pneumonia and arthritis animal groups, respectively). The increased MR expression appeared to be SRLV specific and may have a role in lentiviral pathogenesis.

Idioma: Inglés

DOI: 10.1186/1297-9716-43-43

Año: 2012

Publicado en: VETERINARY RESEARCH 43, 43 (2012), []
ISSN: 0928-4249

Factor impacto JCR: 3.426 (2012)

Categ. JCR: VETERINARY SCIENCES rank: 1 / 142 = 0.007 (2012) - Q1 - T1

Financiación: info:eu-repo/grantAgreement/ES/CICYT/AGL2010-22341-C04-01

Tipo y forma: Article (Published version)

Área (Departamento): Sanidad Animal (Departamento de Patología Animal)