Resumen: Herein, we report our preliminary results concerning the first promising asymmetric synthesis of highly functionalized 2-oxospiro-indole-3, 4'-(1', 4'-dihydropyridine)] via the reaction of an enamine with isatylidene malononitrile derivatives in the presence of a chiral base organocatalyst. The moderate, but promising, enantioselectivity observed (30%–58% ee (enantiomeric excess)) opens the door to a new area of research for the asymmetric construction of these appealing spirooxindole skeletons, whose enantioselective syntheses are still very limited. Idioma: Inglés DOI: 10.3390/molecules200915807 Año: 2015 Publicado en: Molecules 20, 9 (2015), 15807-15826 ISSN: 1420-3049 Factor impacto JCR: 2.465 (2015) Categ. JCR: CHEMISTRY, ORGANIC rank: 24 / 59 = 0.407 (2015) - Q2 - T2 Factor impacto SCIMAGO: 0.57 - Analytical Chemistry (Q2) - Chemistry (miscellaneous) (Q2) - Drug Discovery (Q2) - Physical and Theoretical Chemistry (Q2) - Medicine (miscellaneous) (Q2) - Organic Chemistry (Q2) - Pharmaceutical Science (Q2) - Molecular Medicine (Q3)