Selective delivery of photothermal nanoparticles to tumors using mesenchymal stem cells as Trojan horses
Encabo-Berzosa, M. Mar (Universidad de Zaragoza) ; Gimeno, Marina ; Luján, Lluis (Universidad de Zaragoza) ; Sancho-Albero, María (Universidad de Zaragoza) ; Gómez, Leire ; Sebastián, Víctor (Universidad de Zaragoza) ; Quintanilla, Miguel ; Arruebo, Manuel (Universidad de Zaragoza) ; Santamaría, Jesús (Universidad de Zaragoza) ; Martín-Duque, Pilar
Resumen: The main challenge of cancer treatment is to avoid or minimize systemic side effects in off-target tissues. Mesenchymal stem cells (MSCs) can be used as therapeutical carriers because of their ability to migrate and incorporate into inflammation areas including tumors. Here, this homing ability is exploited by carrying therapeutic nanoparticles (Hollow Gold Nanoparticles (HGNs)) following a “Trojan-horse” strategy. Amongst the different nanoparticles to be employed, HGNs have the capacity to resonate in the near infrared region when irradiated by an appropriated laser (808 nm). By transforming this absorbed energy into heat, they are capable to produce locally induced hyperthermia. At this wavelength healthy tissues have a minimal light absorption being the effect restricted to the tissues containing HGNs. By placing HGNs inside MSCs, the recognition, excretion and immune response are minimized. We demonstrate that MSCs internalize HGNs and reach the tumors still containing HGNs. After laser treatment this loaded cells are able to eradicate tumoral cells in vitro and in vivo without significant toxicity. Also Ki67 expression, which is usually correlated with proliferation, is reduced after treatment. This approach enhances the effectiveness of the treatment when compared to just the enhanced permeation and retention effect (EPR) of the HGNs by themselves.
Idioma: Inglés
DOI: 10.1039/C6RA10058A
Año: 2016
Publicado en: RSC Advances 6, 63 (2016), 58723-58732
ISSN: 2046-2069
Factor impacto JCR: 3.108 (2016)
Categ. JCR: CHEMISTRY, MULTIDISCIPLINARY rank: 59 / 166 = 0.355 (2016) - Q2 - T2
Factor impacto SCIMAGO: 0.889 - Chemistry (miscellaneous) (Q1) - Chemical Engineering (miscellaneous) (Q1)
Financiación: info:eu-repo/grantAgreement/EC/FP7/614715/EU/A Photo-triggered On-demand Drug Delivery System for Chronic Pain/NANOHEDONISM
Tipo y forma: Article (PostPrint)
Área (Departamento): Área Sanidad Animal (Dpto. Patología Animal)
Área (Departamento): Área Ingeniería Química (Dpto. Ing.Quím.Tecnol.Med.Amb.)
You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use. You may not use the material for commercial purposes.
Exportado de SIDERAL (2021-11-15-14:34:07)
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Idioma: Inglés
DOI: 10.1039/C6RA10058A
Año: 2016
Publicado en: RSC Advances 6, 63 (2016), 58723-58732
ISSN: 2046-2069
Factor impacto JCR: 3.108 (2016)
Categ. JCR: CHEMISTRY, MULTIDISCIPLINARY rank: 59 / 166 = 0.355 (2016) - Q2 - T2
Factor impacto SCIMAGO: 0.889 - Chemistry (miscellaneous) (Q1) - Chemical Engineering (miscellaneous) (Q1)
Financiación: info:eu-repo/grantAgreement/EC/FP7/614715/EU/A Photo-triggered On-demand Drug Delivery System for Chronic Pain/NANOHEDONISM
Tipo y forma: Article (PostPrint)
Área (Departamento): Área Sanidad Animal (Dpto. Patología Animal)
Área (Departamento): Área Ingeniería Química (Dpto. Ing.Quím.Tecnol.Med.Amb.)
You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use. You may not use the material for commercial purposes. Exportado de SIDERAL (2021-11-15-14:34:07)
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Record created 2017-06-12, last modified 2021-11-17