Dual encapsulation of hydrophobic and hydrophilic drugs in PLGA nanoparticles by a single-step method: Drug delivery and cytotoxicity assays

Español, L. ; Larrea, A. (Universidad de Zaragoza) ; Andreu, V. ; Mendoza, G. ; Arruebo, M. (Universidad de Zaragoza) ; Sebastian, V. (Universidad de Zaragoza) ; Aurora-Prado, M.S. ; Kedor-Hackmann, E.R.M. ; Santoro, M.I.R.M. ; Santamaria, J. (Universidad de Zaragoza)

Resumen: Dual drug encapsulation in biodegradable nanoparticles is always challenging and often requires strenuous optimization of the synthesis-encapsulation processes. This becomes even more difficult when the simultaneous encapsulation of molecules of different polarity is sought. Here we present a modified emulsification-evaporation process to produce polymeric nanoparticles (NPs) made of the biocompatible and biodegradable polymer poly(lactic-co-glycolic acid) (PLGA) and co-encapsulating simultaneously two different drugs, the hydrophobic dexamethasone (DX) and the hydrophilic diclofenac sodium (DS). Three independent processing parameters were systematically modified to promote the incorporation of the different-polarity drugs into PLGA and to control the particle size under 150 nm. The careful selection of the appropriate solvents (ethyl acetate and methanol) was a key requirement for the successful encapsulation of DX and DS. DS and DX release kinetics as well as cytotoxicity assays underlined the therapeutic potential of the dual encapsulation strategy. © 2016 The Royal Society of Chemistry.

Idioma: Inglés

DOI: 10.1039/c6ra23620k

Año: 2016

Publicado en: RSC Advances 6, 112 (2016), 111060-111069
ISSN: 2046-2069

Factor impacto JCR: 3.108 (2016)

Categ. JCR: CHEMISTRY, MULTIDISCIPLINARY rank: 59 / 166 = 0.355 (2016) - Q2 - T2

Factor impacto SCIMAGO: 0.889 - Chemistry (miscellaneous) (Q1) - Chemical Engineering (miscellaneous) (Q1)

Financiación: info:eu-repo/grantAgreement/EC/FP7/321642/EU/Development of a microfluidic platform to produce nanomaterials and assessment on new nanotechnology applications/PLATFORM2NANO
Financiación: info:eu-repo/grantAgreement/EC/FP7/614715/EU/A Photo-triggered On-demand Drug Delivery System for Chronic Pain/NANOHEDONISM

Tipo y forma: Article (Published version)

Área (Departamento): Área Ingeniería Química (Dpto. Ing.Quím.Tecnol.Med.Amb.)