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> Dual encapsulation of hydrophobic and hydrophilic drugs in PLGA nanoparticles by a single-step method: Drug delivery and cytotoxicity assays
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Dual encapsulation of hydrophobic and hydrophilic drugs in PLGA nanoparticles by a single-step method: Drug delivery and cytotoxicity assays
Español, L.
;
Larrea, A.
(Universidad de Zaragoza)
;
Andreu, V.
;
Mendoza, G.
;
Arruebo, M.
(Universidad de Zaragoza)
;
Sebastian, V.
(Universidad de Zaragoza)
;
Aurora-Prado, M.S.
;
Kedor-Hackmann, E.R.M.
;
Santoro, M.I.R.M.
;
Santamaria, J.
(Universidad de Zaragoza)
Resumen:
Dual drug encapsulation in biodegradable nanoparticles is always challenging and often requires strenuous optimization of the synthesis-encapsulation processes. This becomes even more difficult when the simultaneous encapsulation of molecules of different polarity is sought. Here we present a modified emulsification-evaporation process to produce polymeric nanoparticles (NPs) made of the biocompatible and biodegradable polymer poly(lactic-co-glycolic acid) (PLGA) and co-encapsulating simultaneously two different drugs, the hydrophobic dexamethasone (DX) and the hydrophilic diclofenac sodium (DS). Three independent processing parameters were systematically modified to promote the incorporation of the different-polarity drugs into PLGA and to control the particle size under 150 nm. The careful selection of the appropriate solvents (ethyl acetate and methanol) was a key requirement for the successful encapsulation of DX and DS. DS and DX release kinetics as well as cytotoxicity assays underlined the therapeutic potential of the dual encapsulation strategy. © 2016 The Royal Society of Chemistry.
Idioma:
Inglés
DOI:
10.1039/c6ra23620k
Año:
2016
Publicado en:
RSC Advances
6, 112 (2016), 111060-111069
ISSN:
2046-2069
Factor impacto JCR:
3.108 (2016)
Categ. JCR:
CHEMISTRY, MULTIDISCIPLINARY
rank: 59 / 166 = 0.355
(2016)
- Q2
- T2
Factor impacto SCIMAGO:
0.889 -
Chemistry (miscellaneous)
(Q1) -
Chemical Engineering (miscellaneous)
(Q1)
Financiación:
info:eu-repo/grantAgreement/EC/FP7/321642/EU/Development of a microfluidic platform to produce nanomaterials and assessment on new nanotechnology applications/PLATFORM2NANO
Financiación:
info:eu-repo/grantAgreement/EC/FP7/614715/EU/A Photo-triggered On-demand Drug Delivery System for Chronic Pain/NANOHEDONISM
Tipo y forma:
Article (Published version)
Área (Departamento):
Área Ingeniería Química
(
Dpto. Ing.Quím.Tecnol.Med.Amb.
)
Exportado de SIDERAL (2023-02-10-13:59:39)
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Notice créée le 2017-06-12, modifiée le 2023-02-10
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