Morphological Transformation and Force Generation of Active Cytoskeletal Networks
Financiación FP7 / Fp7 Funds
Resumen: Cells assemble numerous types of actomyosin bundles that generate contractile forces for biological processes, such as cytokinesis and cell migration. One example of contractile bundles is a transverse arc that forms via actomyosin-driven condensation of actin filaments in the lamellipodia of migrating cells and exerts significant forces on the surrounding environments. Structural reorganization of a network into a bundle facilitated by actomyosin contractility is a physiologically relevant and biophysically interesting process. Nevertheless, it remains elusive how actin filaments are reoriented, buckled, and bundled as well as undergo tension buildup during the structural reorganization. In this study, using an agent-based computational model, we demonstrated how the interplay between the density of myosin motors and cross-linking proteins and the rigidity, initial orientation, and turnover of actin filaments regulates the morphological transformation of a cross-linked actomyosin network into a bundle and the buildup of tension occurring during the transformation.
Idioma: Inglés
DOI: 10.1371/journal.pcbi.1005277
Año: 2017
Publicado en: PLoS computational biology 13, 1 (2017), e1005277[22 pp]
ISSN: 1553-7358

Factor impacto JCR: 3.955 (2017)
Categ. JCR: MATHEMATICAL & COMPUTATIONAL BIOLOGY rank: 5 / 59 = 0.085 (2017) - Q1 - T1
Categ. JCR: BIOCHEMICAL RESEARCH METHODS rank: 13 / 79 = 0.165 (2017) - Q1 - T1

Factor impacto SCIMAGO: 3.097 - Cellular and Molecular Neuroscience (Q1) - Computational Theory and Mathematics (Q1) - Ecology (Q1) - Molecular Biology (Q1) - Genetics (Q1) - Modeling and Simulation (Q1) - Ecology, Evolution, Behavior and Systematics (Q1)

Financiación: info:eu-repo/grantAgreement/EUR/FP7/ERC2012-StG-306751
Tipo y forma: Article (Published version)
Área (Departamento): Área Mec.Med.Cont. y Teor.Est. (Dpto. Ingeniería Mecánica)

Creative Commons You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.


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