Metal-organic frameworks (MOFs) bring new life to hydrogen-bonding organocatalysts in confined spaces

Alegre-Requena, Juan V. ; Marqués-López, María Eugenia (Universidad de Zaragoza) ; Herrera, Raquel P. (Universidad de Zaragoza) ; Díaz Díaz, David

Resumen: Hydrogen-bonding organocatalysis has emerged as a promising biomimetic alternative to Lewis acid catalysis. Urea, thiourea and squaramide moieties represent the most common hydrogen-bond donors used for the preparation of these catalysts. However, their significant tendency to undergo self-quenching (self-aggregation) often decreases their solubility and reactivity. Recently, scientists have found a promising way around this problem by immobilizing the hydrogen-bonding organocatalysts on metal–organic frameworks (MOFs). Along with advantageous modular synthesis and recycling properties, the tunable porosity and topology of MOFs also allows fast mass transport and/or interactions with substrates. Herein, we highlight the existing examples dealing with the fabrication and testing of hydrogen-bonding organocatalyst-containing MOFs, providing also our vision for further advances in this area. The results derived from these studies will likely serve as inspiration for the future development of superior hydrogen-bonding organocatalysts to accomplish in confined spaces chemical transformations that are either slow or unaffordable under standard homogeneous conditions.

Idioma: Inglés

DOI: 10.1039/C5CE02526E

Año: 2016

Publicado en: CRYSTENGCOMM 18, 22 (2016), 3985-3995
ISSN: 1466-8033

Factor impacto JCR: 3.474 (2016)

Categ. JCR: CRYSTALLOGRAPHY rank: 5 / 26 = 0.192 (2016) - Q1 - T1
Categ. JCR: CHEMISTRY, MULTIDISCIPLINARY rank: 49 / 166 = 0.295 (2016) - Q2 - T1

Factor impacto SCIMAGO: 1.052 - Chemistry (miscellaneous) (Q1) - Materials Science (miscellaneous) (Q1) - Condensed Matter Physics (Q1)

Financiación: info:eu-repo/grantAgreement/ES/CSIC/PIE-201580I010
Financiación: info:eu-repo/grantAgreement/ES/DGA/E104
Financiación: info:eu-repo/grantAgreement/ES/UZ/JIUZ-2014-CIE-07

Tipo y forma: Article (PostPrint)

Área (Departamento): Área Química Orgánica (Dpto. Química Orgánica)