Incidence Patterns and Trends of non-Central Nervous System Solid Tumours in Children and Adolescents. A Collaborative Study of the Spanish Population Based Cancer Registries
Larrañaga, N. ; Sanchez, M.J. ; Ardanaz, E. ; Felipe, S. ; Marcos-Gragera, R. ; Ramos, M. ; Carulla, M. ; Chirlaque, M.D. ; Argüelles, M.V. ; Martos, C. ; Mateo, A. ; Peris-Bonet, R.
Resumen: Objective: To describe incidence patterns and trends in children (0-14 years) and adolescents (15-19 age-range) with solid tumours, except those of central nervous system (CNS), in Spain. Methods: Cases were drawn from eleven Spanish population-based cancer registries. Incidence was estimated for the period 1983-2007 and trends were evaluated using Joinpoint regression analysis. Results: The studied tumour groups accounted for 36% of total childhood cancers and 47.6% of those diagnosed in adolescence with annual rates per million of 53.5 and 89.3 respectively. In children 0 to 14 years of age, Neuroblastoma (NB) was the commonest (7.8%) followed by Soft-tissue sarcomas (STS) (6.3%), bone tumours (BT) (6.2%) and renal tumours (RT) (4.5%). NB was the most frequently diagnosed tumour before the 5th birthday, while STS and BT were the commonest at 5-9 years of age, and BT and Carcinoma and other epithelial tumours (COET) at 10-14. COET presented the highest incidence in adolescents, followed by germ-cell tumours (GCT), BT and STS. These four diagnostic groups accounted for 94% of total non-CNS solid tumours, in adolescents. Overall incidence rates increased significantly in children up to 1996 with an annual percentage change (APC) of 2.6% (95% CI: 1.7; 3.6). NB and COET showed significant time trend (APCs: 1.4% and 3.8% respectively) while other tumour groups such as RT, STS, BT or GCT had no significant changes over time. A significant increase was present in NB under the age of 5 and in BT and STS in children aged 10-14 years. In adolescents there were significant increases for all tumours combined (APC=2.7; 95% CI: 1.8-3.6) and for STS, GCT and COET (APCs: 3.2%, 4.4% and 3.5% respectively), while other tumour groups such as hepatic tumours, BT or thyroid carcinomas showed a decreasing trend or no increase. Conclusions: Overall, the incidence of the studied cancers in children increased along the period 1983-1996 with no posterior significant rise, while the incidence in adolescents increased significantly over the whole period 1983-2007. Several specific tumour groups showed significant rises or decrements in childhood or adolescence, although the small number of cases precludes showing significant trends or inflexion points.
Idioma: Inglés
DOI: 10.7150/jca.12943
Año: 2016
Publicado en: Journal of cancer (Wyoming, N.S.W.) 7, 3 (2016), 335-343
ISSN: 1837-9664
Factor impacto JCR: 2.916 (2016)
Categ. JCR: ONCOLOGY rank: 113 / 217 = 0.521 (2016) - Q3 - T2
Factor impacto SCIMAGO: 1.207 - Oncology (Q2)
Financiación: info:eu-repo/grantAgreement/ES/FIS/PI-061742
Tipo y forma: Article (Published version)
You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use. You may not use the material for commercial purposes.
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Idioma: Inglés
DOI: 10.7150/jca.12943
Año: 2016
Publicado en: Journal of cancer (Wyoming, N.S.W.) 7, 3 (2016), 335-343
ISSN: 1837-9664
Factor impacto JCR: 2.916 (2016)
Categ. JCR: ONCOLOGY rank: 113 / 217 = 0.521 (2016) - Q3 - T2
Factor impacto SCIMAGO: 1.207 - Oncology (Q2)
Financiación: info:eu-repo/grantAgreement/ES/FIS/PI-061742
Tipo y forma: Article (Published version)
You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use. You may not use the material for commercial purposes. Exportado de SIDERAL (2020-02-21-13:52:39)
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Record created 2018-05-21, last modified 2020-02-21