Dietary fat intake modifies the influence of the FTO rs9939609 polymorphism on adiposity in adolescents: the HELENA cross-sectional study
Financiación FP6 / FP6 Funds
Resumen: Background and aims The fat mass and obesity associated gene (FTO) has been associated with obesity and dietary intake. The aims were: (i) To assess whether energy and macronutrient intakes were different across the FTOrs9939609 genotypes in adolescents, and (ii) to explore whether dietary fat intake modified the association of the rs9939609 polymorphism with adiposity. Methods and results The FTOrs9939609 polymorphism was genotyped in 652 adolescents (53% females, 14.8 ± 1.2 years, TT = 246, TA = 296, AA = 110). Energy and macronutrient intake were assessed by two non-consecutive 24 h-recalls. Weight, height, waist circumference and skinfold thicknesses were measured and body fat percent was calculated. Energy and macronutrient intake were similar across the FTOrs9939609 genotypes (P > 0.2). There were significant interactions between the FTO polymorphism and fat intake on adiposity estimates (P < 0.05). In adolescents whose fat intake was below 30% (N = 203), the A allele of rs9939609 was not associated with adiposity indices. In contrast, in adolescents whose fat intake was between 30% and 35% of energy (N = 190), the rs9939609 polymorphism was associated with a 1.9% higher body fat per risk allele (95%CI: 0.39, 3.33; P < 0.05), and in those whose fat intake was higher than 35% (N = 259), it was associated with a 2.8% higher body fat per risk allele (95%CI: 1.27, 4.43; P < 0.001). Conclusions These findings support the concept that the deleterious effect of the FTOrs9939609 polymorphism on adiposity is exacerbated in adolescents consuming high fat diets. In contrast, the consumption of low fat diets (<30% of energy) may attenuate the genetic predisposition to obesity in risk allele carriers.
Idioma: Inglés
DOI: 10.1016/j.numecd.2016.07.010
Año: 2016
ISSN: 0939-4753

Factor impacto JCR: 3.679 (2016)
Categ. JCR: CARDIAC & CARDIOVASCULAR SYSTEMS rank: 42 / 126 = 0.333 (2016) - Q2 - T2
Categ. JCR: NUTRITION & DIETETICS rank: 21 / 81 = 0.259 (2016) - Q2 - T1
Categ. JCR: ENDOCRINOLOGY & METABOLISM rank: 47 / 138 = 0.341 (2016) - Q2 - T2

Factor impacto SCIMAGO: 1.588 - Cardiology and Cardiovascular Medicine (Q1) - Nutrition and Dietetics (Q1) - Medicine (miscellaneous) (Q1) - Endocrinology, Diabetes and Metabolism (Q1)

Financiación: info:eu-repo/grantAgreement/EUR/FP6/FOOD-CT-2005-6007034
Financiación: info:eu-repo/grantAgreement/ES/MINECO/RYC-2010-05957
Financiación: info:eu-repo/grantAgreement/ES/Spanish Ministry of Health/CIBERobn CB12-03-30038
Tipo y forma: Article (PostPrint)
Área (Departamento): Área Enfermería (Dpto. Fisiatría y Enfermería)

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 Record created 2018-05-22, last modified 2020-02-21

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