Efficient production of hybrid bio-nanomaterials by continuous microchannel emulsification: Dye-doped SiO2 and Au-PLGA nanoparticles

Larrea, A. ; Clemente, A. (Universidad de Zaragoza) ; Luque-Michel, E. ; Sebastian, V. (Universidad de Zaragoza)

Resumen: A novel microfluidic system was designed to produce in a continuous manner hybrid nanomaterials using the microchannel double w/o/w emulsification technique. Double w/o/w nanoemulsions were produced combining two inter-digital micromixers that afford working in continuous flow and with a high reproducibility and control on the reaction conditions. High throughput production of two hybrid nanomaterials, dye-doped SiO2 (4 mg/min) and Au-loaded poly(lactic-co-glycolic) acid (PLGA) (168 mg/min) nanoparticles, were achieved, showing the resulting nanomaterials excellent and reproducible optical properties and tunable loading. These hybrid nanomaterials could be potentially used in different biomedical applications. In addition, the microfluidic system designed for carrying out double emulsification enabled to decrease the particle size distribution of dye-doped SiO2 nanoparticles (NPs) up to 20 nm and to improve the Au NPs loading efficiency in Au-loaded PLGA hybrid nanoparticles. The excellent control achieved in the Au NPs loading allowed tuning the payload on demand. Finally, the microfluidic system designed in this work overpasses the productivity described in previously published batch-type reactors, while assuring the same properties of the resulting hybrid nanomaterials.

Idioma: Inglés

DOI: 10.1016/j.cej.2017.02.003

Año: 2017

Publicado en: Chemical Engineering Journal 316 (2017), 663-672
ISSN: 1385-8947

Factor impacto JCR: 6.735 (2017)

Categ. JCR: ENGINEERING, ENVIRONMENTAL rank: 3 / 50 = 0.06 (2017) - Q1 - T1
Categ. JCR: ENGINEERING, CHEMICAL rank: 7 / 137 = 0.051 (2017) - Q1 - T1

Factor impacto SCIMAGO: 1.863 - Chemical Engineering (miscellaneous) (Q1) - Industrial and Manufacturing Engineering (Q1) - Environmental Chemistry (Q1) - Chemistry (miscellaneous) (Q1)

Financiación: info:eu-repo/grantAgreement/ES/DGA/FSE
Financiación: info:eu-repo/grantAgreement/EC/FP7/321642/EU/Development of a microfluidic platform to produce nanomaterials and assessment on new nanotechnology applications/PLATFORM2NANO

Tipo y forma: Article (PostPrint)

Área (Departamento): Área Ingeniería Química (Dpto. Ing.Quím.Tecnol.Med.Amb.)