A perspective on structural and mechanistic aspects of protein O-fucosylation
Financiación FP7 / Fp7 Funds
Resumen: Protein O-fucosylation is an important post-translational modification (PTM) found in cysteine-rich repeats in proteins. Protein O-fucosyltransferases 1 and 2 (PoFUT1 and PoFUT2) are the enzymes responsible for this PTM and selectively glycosylate specific residues in epidermal growth factor-like (EGF) repeats and thrombospondin type I repeats (TSRs), respectively.Within the past six years, crystal structures of both enzymes have been reported, revealing important information on how they recognize protein substrates and achieve catalysis. Here, the structural information available today is summarized and how PoFUT1 and PoFUT2 employ different catalytic mechanisms is discussed.
Idioma: Inglés
DOI: 10.1107/S2053230X18004788
Año: 2018
Publicado en: Acta Crystallographica Section F-Structural Biology Communications 74, 8 (2018), 443-450
ISSN: 2053-230X

Factor impacto SCIMAGO: 0.701 - Biochemistry (Q2) - Biophysics (Q2) - Structural Biology (Q2) - Genetics (Q2) - Medicine (miscellaneous) (Q2) - Condensed Matter Physics (Q2)

Financiación: info:eu-repo/grantAgreement/ES/DGA/B89
Financiación: info:eu-repo/grantAgreement/EC/FP7/609409/EU/Supporting transnational mobility within the European life sciences by cofunding of the EMBO Fellowship Programme/LTFCOFUND2013
Tipo y forma: Review (Published version)
Área (Departamento): Área Bioquímica y Biolog.Mole. (Dpto. Bioq.Biolog.Mol. Celular)
Exportado de SIDERAL (2020-01-17-21:48:50)


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 Notice créée le 2018-09-24, modifiée le 2020-01-17


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