Mitochondrial DNA Haplogroup JT is Related to Impaired Glycaemic Control and Renal Function in Type 2 Diabetic Patients

Diaz-Morales, N. ; Lopez-Domenech, S. ; Iannantuoni, F. ; Lopez-Gallardo, E. (Universidad de Zaragoza) ; Sola, E. ; Morillas, C. ; Rocha, M. ; Ruiz-Pesini, E. (Universidad de Zaragoza) ; Victor, V.M.

Resumen: The association between mitochondrial DNA (mtDNA) haplogroup and risk of type 2 diabetes (T2D) is undetermined and controversial. This study aims to evaluate the impact of the main mtDNA haplogroups on glycaemic control and renal function in a Spanish population of 303 T2D patients and 153 healthy controls. Anthropometrical and metabolic parameters were assessed and mtDNA haplogroup was determined in each individual. Distribution of the different haplogroups was similar in diabetic and healthy populations and, as expected, T2D patients showed poorer glycaemic control and renal function than controls. T2D patients belonging to the JT haplogroup (polymorphism m.4216T>C) displayed statistically significant higher levels of fasting glucose and HbA(1c) than those of the other haplogroups, suggesting a poorer glycaemic control. Furthermore, diabetic patients with the JT haplogroup showed a worse kidney function than those with other haplogroups, evident by higher levels of serum creatinine, lower estimated glomerular filtration rate (eGFR), and slightly higher (although not statistically significant) urinary albumin-to-creatinine ratio. Our results suggest that JT haplogroup (in particular, change at position 4216 of the mtDNA) is associated with poorer glycaemic control in T2D, which can trigger the development of diabetic nephropathy.

Idioma: Inglés

DOI: 10.3390/jcm7080220

Año: 2018

Publicado en: Journal of Clinical Medicine 7, 8 (2018), 220
ISSN: 2077-0383

Factor impacto JCR: 5.688 (2018)

Categ. JCR: MEDICINE, GENERAL & INTERNAL rank: 15 / 159 = 0.094 (2018) - Q1 - T1

Factor impacto SCIMAGO: 2.274 - Medicine (miscellaneous) (Q1)

Financiación: info:eu-repo/grantAgreement/ES/DGA/B33-17R
Financiación: info:eu-repo/grantAgreement/ES/ISCIII/CIBERehd/CB06-04-0071
Financiación: info:eu-repo/grantAgreement/ES/ISCIII/FI14-00125
Financiación: info:eu-repo/grantAgreement/ES/ISCIII/FI14-00350
Financiación: info:eu-repo/grantAgreement/ES/ISCIII/PI14-00070
Financiación: info:eu-repo/grantAgreement/ES/ISCIII/PI16-0301
Financiación: info:eu-repo/grantAgreement/ES/ISCIII/PI16-1083
Financiación: info:eu-repo/grantAgreement/ES/ISCIII/PI17-00166

Tipo y forma: Article (Published version)

Área (Departamento): Área Bioquímica y Biolog.Mole. (Dpto. Bioq.Biolog.Mol. Celular)