ECG-based estimation of dispersion of APD restitution as a tool to stratify sotalol-induced arrhythmic risk

Mincholé, A. ; Bueno-Orovio, A. ; Laguna, P. (Universidad de Zaragoza) ; Pueyo, E. (Universidad de Zaragoza) ; Rodriguez, B.

Resumen: Background
Increased spatial dispersion of restitution properties has been associated to arrhythmic risk. An ECG-based index quantifying restitution dispersion, DRest, is evaluated in patients who experienced Torsades de Pointes (TdP) under sotalol challenge and compared with the response in healthy subjects.
Methods and Results
ECG recordings were analyzed for quantification of DRest and QTc, among others biomarkers. DRest provides improved discrimination following sotalol administration between TdP and healthy subjects ([min–max]: [0.18–0.22] vs [0.02–0.12]), compared to other biomarkers including QTc ([436–548 ms] vs [376–467 ms]). Results in healthy subjects are in agreement with simulations of sotalol effects on a human tissue electrophysiological model.
Conclusions
This case study supports the potential of DRest for improved arrhythmia risk stratification even with QTc values below 450 ms.

Idioma: Inglés

DOI: 10.1016/j.jelectrocard.2015.06.006

Año: 2015

Publicado en: JOURNAL OF ELECTROCARDIOLOGY 48, 5 (2015), 867-873
ISSN: 0022-0736

Factor impacto JCR: 1.29 (2015)

Categ. JCR: CARDIAC & CARDIOVASCULAR SYSTEMS rank: 93 / 124 = 0.75 (2015) - Q3 - T3

Factor impacto SCIMAGO: 0.559 - Cardiology and Cardiovascular Medicine (Q2)

Financiación: info:eu-repo/grantAgreement/ES/MINECO/TEC2013-42140-R
Financiación: info:eu-repo/grantAgreement/ES/MINECO/TIN2013-41998-R

Tipo y forma: Article (Published version)

Área (Departamento): Área Teoría Señal y Comunicac. (Dpto. Ingeniería Electrón.Com.)