Genetic susceptibility in the development of colorectal adenomas according to family history of colorectal cancer
Gargallo, C.J. (Universidad de Zaragoza) ; Lanas, Á. (Universidad de Zaragoza) ; Carrera-Lasfuentes, P. ; Ferrandez, Á. ; Quintero, E. ; Carrillo, M. ; Alonso-Abreu, I. ; García-Gonzalez, M.A.
Resumen: Our study aimed to evaluate the relevance of genetic susceptibility in the development of colorectal adenomas (CRA) and its relationship with the presence of family history of colorectal cancer (CRC). Genomic DNA from 750 cases (first degree relatives of patients with CRC) and 750 controls (subjects with no family history of CRC) was genotyped for 99 single nucleotide polymorphisms (SNPs) previously associated with CRC/CRA risk by GWAS and candidate gene studies by using the MassArray™ (Sequenom) platform. Cases and controls were matched by gender, age and histological lesion. Eight hundred and fifty-eight patients showed no neoplastic lesions, whereas 288 patients showed low-risk adenomas, and 354 patients presented high-risk adenomas. Two SNPs (rs10505477, rs6983267) in the CASC8 gene were associated with a reduced risk of CRA in controls (log-additive models, OR: 0.67, 95%CI:0.54–0.83, and OR:0.66, 95%CI:0.54–0.84, respectively). Stratified analysis by histological lesion revealed the association of rs10505477 and rs6983267 variants with reduced risk of low- and high-risk adenomas in controls, being this effect stronger in low-risk adenomas (log-additive models, OR:0.63, 95%CI:0.47–0.84 and OR:0.64, 95%CI:0.47–0.86, respectively). Moreover, 2 SNPs (rs10795668, rs11255841) in the noncoding LINC00709 gene were significantly associated with a reduced risk of low-risk adenomas in cases (recessive models, OR:0.22, 95%CI:0.06–0.72, and OR:0.08, 95%CI:0.03–0.61) and controls (dominant models, OR:0.50, 95%CI:0.34–0.75, and OR:0.52, 95%CI:0.35–0.78, respectively). In conclusion, some variants associated with CRC risk (rs10505477, rs6983267, rs10795668 and rs11255841) are also involved in the susceptibility to CRA and specific subtypes. These associations are influenced by the presence of family history of CRC.
Idioma: Inglés
DOI: 10.1002/ijc.31858
Año: 2018
Publicado en: INTERNATIONAL JOURNAL OF CANCER 144 (2018), 489-502
ISSN: 0020-7136
Factor impacto JCR: 4.982 (2018)
Categ. JCR: ONCOLOGY rank: 51 / 229 = 0.223 (2018) - Q1 - T1
Factor impacto SCIMAGO: 3.276 - Oncology (Q1) - Cancer Research (Q1)
Tipo y forma: Article (Published version)
Área (Departamento): Area Medicina (Dpto. Medicina, Psiqu. y Derm.)
You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use. You may not use the material for commercial purposes.
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Idioma: Inglés
DOI: 10.1002/ijc.31858
Año: 2018
Publicado en: INTERNATIONAL JOURNAL OF CANCER 144 (2018), 489-502
ISSN: 0020-7136
Factor impacto JCR: 4.982 (2018)
Categ. JCR: ONCOLOGY rank: 51 / 229 = 0.223 (2018) - Q1 - T1
Factor impacto SCIMAGO: 3.276 - Oncology (Q1) - Cancer Research (Q1)
Tipo y forma: Article (Published version)
Área (Departamento): Area Medicina (Dpto. Medicina, Psiqu. y Derm.)
You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use. You may not use the material for commercial purposes. Exportado de SIDERAL (2020-10-23-16:54:59)
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Record created 2018-12-18, last modified 2020-10-23