Effects of exercise on the cognition of older women treated with lovastatin

Molina-Sotomayor, E. ; Arreguin-Moreno, R. ; Rodriguez, F. ; Pradas, F. (Universidad de Zaragoza) ; Leon, J.A. ; Gonzalez-Jurado, J.A.

Resumen: Introduction: The deterioration of cognition is highly predominant in older adults. Objective: The aim of this study was to analyse the effects of a walk program on the cognition and blood concentration of lipids in women over 60 years of age who were being treated with Lovastatin.
Materials and methods: Participants were distributed in two groups: an exercise group (EG, n=45) with aerobic training and an inactive sedentary group (SG, n=22). The cognitive state of the subjects was assessed through the Spanish Mini-Cog Test version of the MMSE; lipoproteins were quantified using a lipid profile test and the cardiorespiratory fitness was measured using the 6 min Walk Test (6MWT).
Results: EG showed a significant increase (p<0.05) in cardiorespiratory fitness and in HDL-C concentrations. Furthermore, the results from the cognition tests showed a large effect size in spatial orientation and attention and calculation. The decrease in LDL-C was not significant (p>0.05).
Conclusion: A controlled and progressive walk program for older women treated with Lovastatin may induce a boost of brain activity linked to HDL-C, which could delay cognitive impairment.

Idioma: Inglés

DOI: 10.3233/JAD-170014

Año: 2018

Publicado en: Biomedica 38, 4 (2018), [33 pp]
ISSN: 0120-4157

Factor impacto JCR: 0.733 (2018)

Categ. JCR: TROPICAL MEDICINE rank: 17 / 21 = 0.81 (2018) - Q4 - T3

Factor impacto SCIMAGO: 0.276 - Medicine (miscellaneous) (Q3) - Biochemistry, Genetics and Molecular Biology (miscellaneous) (Q3)

Tipo y forma: Article (Published version)

Área (Departamento): Área Didáctica Expres.Corporal (Dpto. Expres.Music.Plást.Corp.)