Ideal cardiovascular health and inflammation in European adolescents: The HELENA study

González-Gil, E.M. (Universidad de Zaragoza) ; Santabárbara, J. (Universidad de Zaragoza) ; Ruiz, J.R. ; Bel-Serrat, S. ; Huybrechts, I. ; Pedrero-Chamizo, R. ; de la O, A. ; Gottrand, F. ; Kafatos, A. ; Widhalm, K. ; Manios, Y. ; Molnar, D. ; de Henauw, S. ; Plada, M. ; Ferrari, M. ; Palacios Le Blé, G. ; Siani, A. ; González-Gross, M. ; Gómez-Martínez, S. ; Marcos, A. ; Moreno Aznar, L.A. ; Moreno, L.A. (Universidad de Zaragoza) ; Gottrand, F. ; de Henauw, S. ; González-Gross, M. ; Gilbert, C. ; Kafatos, A. ; Libersa, C. ; Castelló, S. ; Kersting, M. ; Sjöstrom, M. ; Molnár, D. ; Dallongeville, J. ; Hall, G. ; Maes, L. ; Scalfi, L. ; Meléndez, P. ; Fleta, J. ; Casajús, J.A. ; Rodríguez, G. ; Tomás, C. ; Mesana, M.I. ; Vicente-Rodríguez, G. ; Villarroya, A. ; Gil, C.M. ; Ara, I. ; Alvira, J.F. ; Bueno, G. ; Lázaro, A. ; Bueno, O. ; León, J.F. ; Garagorri, J.M. ; Bueno, M. ; Labayen, I. ; Iglesia, I. ; Bel Serrat, S. ; Gracia Marco, L.A. ; Mouratidou, T. ; Santaliestra-Pasías, A. ; González-Gil, E.M. ; de Miguel-Etayo, P. ; Julián Almárcegui, C. ; Miguel-Berges, M. ; Iguacel, I. ; Marcos, A. ; Wärnberg, J. ; Nova, E. ; Gómez, S. ; Díaz, L.E. ; Romeo, J. ; Veses, A. ; Zapatera, B. ; Pozo, T. ; Martínez, D. ; Beghin, L. ; Gottrand, F. ; Iliescu, C. ; Von Berlepsch, J. ; Sichert-Hellert, W. ; Koeppen, E. ; Molnar, D. ; Erhardt, E. ; Csernus, K. ; Török, K. ; Bokor, S. ; Angster. ; Nagy, E.Ö. ; Kovács, O. ; Répasi, J. ; Codrington, C. ; Plada, M. ; Papadaki, A. ; Sarri, K. ; Viskadourou, A. ; Hatzis, C. ; Kiriakakis, M. ; Tsibinos, G. ; Vardavas, C. ; Sbokos, M. ; Protoyeraki, E. ; Fasoulaki, M. ; Stehle, P. ; Pietrzik, K. ; Breidenassel, C. ; Spinneker, A. ; Al-Tahan, J. ; Segoviano, M. ; Berchtold, A. ; Bierschbach, C. ; Blatzheim, E. ; Schuch, A. ; Pickert, P. ; Castillo, M.J. ; Gutiérrez, Á. ; Ortega, F.B. ; Ruiz, J.R. ; Artero, E.G. ; España, V. ; Jiménez-Pavón, D. ; Chillón, P. ; Sánchez-Muñoz, C. ; Cuenca, M. ; Arcella, D. ; Azzini, E. ; Barrison, E. ; Bevilacqua, N. ; Buonocore, P. ; Catasta, G. ; Censi, L. ; Ciarapica, D. ; D''Acapito, P. ; Ferrari, M. ; Galfo, M. ; Le Donne, C. ; Leclercq, C. ; Maiani, G. ; Mauro, B. ; Mistura, L. ; Pasquali, A. ; Piccinelli, R. ; Polito, A. ; Roccaldo, R. ; Spada, R. ; Sette, S. ; Zaccaria, M. ; Vitaglione, P. ; Montagnese, C. ; De Bourdeaudhuij, I. ; De Vriendt, T. ; Matthys, C. ; Vereecken, C. ; de Maeyer, M. ; Ottevaere, C. ; Huybrechts, I. ; Widhalm, K. ; Phillipp, K. ; Dietrich, S. ; Manios, Y. ; Grammatikaki, E. ; Bouloubasi, Z. ; Cook, T.L. ; Eleutheriou, S. ; Consta, O. ; Moschonis, G. ; Katsaroli, I. ; Kraniou, G. ; Papoutsou, S. ; Keke, D. ; Petraki, I. ; Bellou, E. ; Tanagra, S. ; Kallianoti, K. ; Argyropoulou, D. ; Tsikrika, S. ; Karaiskos, C. ; Meirhaeghe, A. ; Ortega, F.B. ; Hagströmer, M. ; Wennlöf, A.H. ; Hallström, L. ; Patterson, E. ; Kwak, L. ; Rizzo, N. ; Sánchez-Molero, J. ; Picó, E. ; Navarro, M. ; Viadel, B. ; Carreres, J.E. ; Merino, G. ; Sanjuán, R. ; Lorente, M. ; Sánchez, M.J. ; Thomas, S. ; Allchurch, E. ; Burgess, P. ; Astrom, A. ; Sverkén, A. ; Broberg, A. ; Masson, A. ; Lehoux, C. ; Brabant, P. ; Pate, P. ; Fontaine, L. ; Sebok, A. ; Kuti, T. ; Hegyi, A. ; Maldonado, C. ; Llorente, A. ; García, E. ; von Fircks, H. ; Hallberg, M.L. ; Messerer, M. ; Larsson, M.

Resumen: Background and aims
Inflammation plays a key role in atherosclerosis and this process seems to appear in childhood. The ideal cardiovascular health index (ICHI) has been inversely related to atherosclerotic plaque in adults. However, evidence regarding inflammation and ICHI in adolescents is scarce. The aim is to assess the association between ICHI and inflammation in European adolescents.
Methods and results
As many as 543 adolescents (251 boys and 292 girls) from the Healthy Lifestyle in Europe by Nutrition in Adolescence (HELENA) study, a cross-sectional multi-center study including 9 European countries, were measured. C-reactive protein (CRP), complement factors C3 and C4, leptin and white blood cell counts were used to compute an inflammatory score. Multilevel linear models and multilevel logistic regression were used to assess the association between ICHI and inflammation controlling by covariates. Higher ICHI was associated with a lower inflammatory score, as well as with several individual components, both in boys and girls (p < 0.01). In addition, adolescents with at least 4 ideal components of the ICHI had significantly lower inflammatory score and lower levels of the study biomarkers, except CRP. Finally, the multilevel logistic regression showed that for every unit increase in the ICHI, the probability of having an inflammatory profile decreased by 28.1% in girls.
Conclusion
Results from this study suggest that a better ICHI is associated with a lower inflammatory profile already in adolescence. Improving these health behaviors, and health factors included in the ICHI, could play an important role in CVD prevention.

Idioma: Inglés

DOI: 10.1016/j.numecd.2016.12.003

Año: 2017

Publicado en: Nutrition, Metabolism and Cardiovascular Diseases 27, 5 (2017), 447-455
ISSN: 0939-4753

Factor impacto JCR: 3.318 (2017)

Categ. JCR: CARDIAC & CARDIOVASCULAR SYSTEMS rank: 47 / 128 = 0.367 (2017) - Q2 - T2
Categ. JCR: NUTRITION & DIETETICS rank: 27 / 79 = 0.342 (2017) - Q2 - T2
Categ. JCR: ENDOCRINOLOGY & METABOLISM rank: 57 / 141 = 0.404 (2017) - Q2 - T2

Factor impacto SCIMAGO: 1.475 - Endocrinology, Diabetes and Metabolism (Q1) - Nutrition and Dietetics (Q1) - Medicine (miscellaneous) (Q1) - Cardiology and Cardiovascular Medicine (Q1)

Financiación: info:eu-repo/grantAgreement/EUR/FP6/FOOD-CT-2005-007034
Financiación: info:eu-repo/grantAgreement/ES/MINECO/JCI-2010-07055
Financiación: info:eu-repo/grantAgreement/ES/MINECO/RYC-2010-05957

Tipo y forma: Article (PostPrint)

Área (Departamento): Área Enfermería (Dpto. Fisiatría y Enfermería)
Área (Departamento): Área Medic.Prevent.Salud Públ. (Dpto. Microb.Med.Pr.,Sal.Públ.)