CD30-positive primary cutaneous lymphoproliferative disorders: molecular alterations and targeted therapies
Prieto-Torres, L. ; Rodriguez-Pinilla, S.M. ; Onaindia, A. ; Ara, M. (Universidad de Zaragoza) ; Requena, L. ; Piris, M.Á.
Resumen: Primary cutaneous CD30-positive T-cell lymphoproliferative disorders are the second most common subgroup of cutaneous T-cell lymphomas. They include two clinically different entities with some overlapping features and borderline cases: lymphomatoid papulosis and primary cutaneous anaplastic large cell lymphoma. Molecular studies of primary cutaneous anaplastic large cell lymphoma reveal an increasing level of heterogeneity that is associated with histological and immunophenotypic features of the cases and their response to specific therapies. Here, we review the most significant genetic, epigenetic and molecular alterations described to date in primary cutaneous CD30-positive T-cell lymphoproliferative disorders, and their potential as therapeutic targets.
Idioma: Inglés
DOI: 10.3324/haematol.2018.197152
Año: 2019
Publicado en: Haematologica 104, 2 (2019), 226-235
ISSN: 0390-6078
Factor impacto JCR: 7.116 (2019)
Categ. JCR: HEMATOLOGY rank: 7 / 76 = 0.092 (2019) - Q1 - T1
Factor impacto SCIMAGO: 2.931 - Hematology (Q1)
Financiación: info:eu-repo/grantAgreement/ES/MINECO-RTICC-ISCIII-CIBERONC/PIE15-0081
Financiación: info:eu-repo/grantAgreement/ES/MINECO-RTICC-ISCIII-CIBERONC/PI16-01294
Financiación: info:eu-repo/grantAgreement/ES/MINECO-RTICC-ISCIII-CIBERONC/PI17-2172
Financiación: info:eu-repo/grantAgreement/ES/MINECO-RTICC-ISCIII-CIBERONC/RD06-0020-0107-RD012-0036-0060
Financiación: info:eu-repo/grantAgreement/ES/MINECO-RTICC-ISCIII-CIBERONC/SAF2013-47416-R
Tipo y forma: Review (Published version)
Área (Departamento): Área Dermatología (Dpto. Medicina, Psiqu. y Derm.)
You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use. You may not use the material for commercial purposes.
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Idioma: Inglés
DOI: 10.3324/haematol.2018.197152
Año: 2019
Publicado en: Haematologica 104, 2 (2019), 226-235
ISSN: 0390-6078
Factor impacto JCR: 7.116 (2019)
Categ. JCR: HEMATOLOGY rank: 7 / 76 = 0.092 (2019) - Q1 - T1
Factor impacto SCIMAGO: 2.931 - Hematology (Q1)
Financiación: info:eu-repo/grantAgreement/ES/MINECO-RTICC-ISCIII-CIBERONC/PIE15-0081
Financiación: info:eu-repo/grantAgreement/ES/MINECO-RTICC-ISCIII-CIBERONC/PI16-01294
Financiación: info:eu-repo/grantAgreement/ES/MINECO-RTICC-ISCIII-CIBERONC/PI17-2172
Financiación: info:eu-repo/grantAgreement/ES/MINECO-RTICC-ISCIII-CIBERONC/RD06-0020-0107-RD012-0036-0060
Financiación: info:eu-repo/grantAgreement/ES/MINECO-RTICC-ISCIII-CIBERONC/SAF2013-47416-R
Tipo y forma: Review (Published version)
Área (Departamento): Área Dermatología (Dpto. Medicina, Psiqu. y Derm.)
You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use. You may not use the material for commercial purposes. Exportado de SIDERAL (2020-07-16-08:58:51)
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Record created 2019-03-13, last modified 2020-07-16