Increasing mtDNA levels as therapy for mitochondrial optic neuropathies

Ruiz-Pesini, E. (Universidad de Zaragoza) ; Emperador, S. (Universidad de Zaragoza) ; López-Gallardo, E. (Universidad de Zaragoza) ; Hernández-Ainsa, C. (Universidad de Zaragoza) ; Montoya, J. (Universidad de Zaragoza)

Resumen: Leber hereditary optic neuropathy (LHON) is a rare, inherited mitochondrial disease. No treatment has shown a clear-cut benefit on a clinically meaningful end-point. Primary open-angle glaucoma (POAG) is a frequent, acquired optic neuropathy. Lowering intraocular pressure (IOP) reduces disease progression. However, current methods to decelerate this progression are recognized as being inadequate. Therefore, there is a clear need to look for new therapeutic approaches. The growing evidence indicates that POAG can also be a mitochondrial optic neuropathy (MON). Several risk elements are common for both diseases and all of them decrease mitochondrial (mt)DNA content. Based on these susceptibility factors and their molecular mechanism, we suggest herein pharmacological therapies targeted to increase mtDNA levels, oxidative phosphorylation (OXPHOS) capability, and mitochondrial energy production as treatments for MONs.

Idioma: Inglés

DOI: 10.1016/j.drudis.2018.01.031

Año: 2018

Publicado en: DRUG DISCOVERY TODAY 23, 3 (2018), 493-498
ISSN: 1359-6446

Factor impacto JCR: 6.88 (2018)

Categ. JCR: PHARMACOLOGY & PHARMACY rank: 12 / 266 = 0.045 (2018) - Q1 - T1

Factor impacto SCIMAGO: 2.248 - Pharmacology (Q1) - Drug Discovery (Q1)

Financiación: info:eu-repo/grantAgreement/ES/DGA/B33
Financiación: info:eu-repo/grantAgreement/ES/DGA/FEDER
Financiación: info:eu-repo/grantAgreement/ES/ISCIII/PI14-00070
Financiación: info:eu-repo/grantAgreement/ES/ISCIII/PI17-00021
Financiación: info:eu-repo/grantAgreement/ES/ISCIII/PI17-00166
Financiación: info:eu-repo/grantAgreement/ES/ISCIII/P114-00005

Tipo y forma: Article (PostPrint)

Área (Departamento): Area Histología (Dpto. Anatom.Histolog.Humanas)
Área (Departamento): Área Bioquímica y Biolog.Mole. (Dpto. Bioq.Biolog.Mol. Celular)