Chitosan nanoparticles for combined drug delivery and magnetic hyperthermia: from preparation to in vitro studies
Zamora-Mora, Vanessa ; Fernández-Gutiérrez, Mar ; González-Gómez, Álvaro ; Sanz, Beatriz ; San Román, Julio ; Goya, Gerardo F. (Universidad de Zaragoza) ; Hernández, Rebeca ; Mijangos, Carmen
Resumen: Chitosan nanoparticles (CSNPs) ionically crosslinked with tripolyphosphate salts (TPP) were employed as nanocarriers in combined drug delivery and magnetic hyperthermia (MH) therapy. To that aim, three different ferrofluid concentrations and a constant 5-fluorouracil (5-FU) concentration were efficiently encapsulated to yield magnetic CSNPs with core-shell morphology. In vitro experiments using normal cells, fibroblasts (FHB) and cancer cells, human glioblastoma A-172, showed that CSNPs presented a dose-dependent cytotoxicity and that they were successfully uptaken into both cell lines. The application of a MH treatment in A-172 cells resulted in a cell viability of 67–75% whereas no significant reduction of cell viability was observed for FHB. However, the A-172 cells showed re-growth populations 4 h after the application of the MH treatment when CSNPs were loaded only with ferrofluid. Finally, a combined effect of MH and 5-FU release was observed with the application of a second MH treatment for CSNPs exhibiting a lower amount of released 5-FU. This result demonstrates the potential of CSNPs for the improvement of MH therapies.
Idioma: Inglés
DOI: 10.1016/j.carbpol.2016.09.084
Año: 2017
Publicado en: CARBOHYDRATE POLYMERS 157 (2017), 361-370 [34 p.]
ISSN: 0144-8617
Factor impacto JCR: 5.158 (2017)
Categ. JCR: CHEMISTRY, APPLIED rank: 2 / 71 = 0.028 (2017) - Q1 - T1
Categ. JCR: POLYMER SCIENCE rank: 7 / 87 = 0.08 (2017) - Q1 - T1
Categ. JCR: CHEMISTRY, ORGANIC rank: 6 / 57 = 0.105 (2017) - Q1 - T1
Factor impacto SCIMAGO: 1.428 - Materials Chemistry (Q1) - Polymers and Plastics (Q1) - Organic Chemistry (Q1)
Financiación: info:eu-repo/grantAgreement/ES/MINECO/MAT2010-19326
Financiación: info:eu-repo/grantAgreement/ES/MINECO/MAT2011-24797
Tipo y forma: Article (PostPrint)
Área (Departamento): Área Física Materia Condensada (Dpto. Física Materia Condensa.)
You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use. You may not use the material for commercial purposes. If you remix, transform, or build upon the material, you may not distribute the modified material.
Exportado de SIDERAL (2020-02-17-12:41:58)
Visitas y descargas
Idioma: Inglés
DOI: 10.1016/j.carbpol.2016.09.084
Año: 2017
Publicado en: CARBOHYDRATE POLYMERS 157 (2017), 361-370 [34 p.]
ISSN: 0144-8617
Factor impacto JCR: 5.158 (2017)
Categ. JCR: CHEMISTRY, APPLIED rank: 2 / 71 = 0.028 (2017) - Q1 - T1
Categ. JCR: POLYMER SCIENCE rank: 7 / 87 = 0.08 (2017) - Q1 - T1
Categ. JCR: CHEMISTRY, ORGANIC rank: 6 / 57 = 0.105 (2017) - Q1 - T1
Factor impacto SCIMAGO: 1.428 - Materials Chemistry (Q1) - Polymers and Plastics (Q1) - Organic Chemistry (Q1)
Financiación: info:eu-repo/grantAgreement/ES/MINECO/MAT2010-19326
Financiación: info:eu-repo/grantAgreement/ES/MINECO/MAT2011-24797
Tipo y forma: Article (PostPrint)
Área (Departamento): Área Física Materia Condensada (Dpto. Física Materia Condensa.)
You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use. You may not use the material for commercial purposes. If you remix, transform, or build upon the material, you may not distribute the modified material. Exportado de SIDERAL (2020-02-17-12:41:58)
Permalink:
Visitas y descargas
Este artículo se encuentra en las siguientes colecciones:
Articles > Artículos por área > Física de la Materia Condensada
Record created 2019-05-08, last modified 2020-02-17