RGD-Functionalized Fe3O4 nanoparticles for magnetic hyperthermia
Arriortua, O.K. ; Insausti, M. ; Lezama, L. ; Gil de Muro, I. ; Garaio, E. ; de la Fuente, J.M. (Universidad de Zaragoza) ; Fratila, R.M. ; Morales, M.P. ; Costa, R. ; Eceiza, M. ; Sagartzazu-Aizpurua, M. ; Aizpurua, J.M.
Resumen: To improve the selectivity of magnetic nanoparticles for tumor treatment by hyperthermia, Fe3O4 nanoparticles have been functionalized with a peptide of the type arginine-glycine-aspartate (RGD) following a “click” chemistry approach. The RGD peptide was linked onto the previously coated nanoparticles in order to target avß3 integrin receptors over-expressed in angiogenic cancer cells. Different coatings have been analyzed to enhance the biocompatibility of magnetic nanoparticles. Monodispersed and homogeneous magnetite nanoparticles have been synthesized by the seed growth method and have been characterized using X-ray diffraction, thermogravimetric analysis, infrared spectroscopy, transmission electron microscopy and magnetic measurements. The magnetic hyperthermia efficiency of the nanoparticles has also been investigated and cytotoxicity assays have been perfomed for functionalized nanoparticles.
Idioma: Inglés
DOI: 10.1016/j.colsurfb.2018.02.031
Año: 2018
Publicado en: COLLOIDS AND SURFACES B-BIOINTERFACES 165 (2018), 315-324
ISSN: 0927-7765
Factor impacto JCR: 3.973 (2018)
Categ. JCR: BIOPHYSICS rank: 15 / 72 = 0.208 (2018) - Q1 - T1
Categ. JCR: MATERIALS SCIENCE, BIOMATERIALS rank: 11 / 32 = 0.344 (2018) - Q2 - T2
Categ. JCR: CHEMISTRY, PHYSICAL rank: 49 / 148 = 0.331 (2018) - Q2 - T2
Factor impacto SCIMAGO: 0.957 - Biotechnology (Q1) - Colloid and Surface Chemistry (Q1) - Surfaces and Interfaces (Q1) - Physical and Theoretical Chemistry (Q1) - Medicine (miscellaneous) (Q1)
Financiación: info:eu-repo/grantAgreement/ES/DGA/Fondo Social DGA-grupos DGA
Financiación: info:eu-repo/grantAgreement/ES/MINECO-FEDER/MAT2016-78266-P
Financiación: info:eu-repo/grantAgreement/ES/MINECO/SAF2014-54763-C2-2-R
Tipo y forma: Article (PostPrint)
Área (Departamento): Área Química Orgánica (Dpto. Química Orgánica)
You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use. You may not use the material for commercial purposes. If you remix, transform, or build upon the material, you may not distribute the modified material.
Exportado de SIDERAL (2019-12-12-10:03:49)
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Idioma: Inglés
DOI: 10.1016/j.colsurfb.2018.02.031
Año: 2018
Publicado en: COLLOIDS AND SURFACES B-BIOINTERFACES 165 (2018), 315-324
ISSN: 0927-7765
Factor impacto JCR: 3.973 (2018)
Categ. JCR: BIOPHYSICS rank: 15 / 72 = 0.208 (2018) - Q1 - T1
Categ. JCR: MATERIALS SCIENCE, BIOMATERIALS rank: 11 / 32 = 0.344 (2018) - Q2 - T2
Categ. JCR: CHEMISTRY, PHYSICAL rank: 49 / 148 = 0.331 (2018) - Q2 - T2
Factor impacto SCIMAGO: 0.957 - Biotechnology (Q1) - Colloid and Surface Chemistry (Q1) - Surfaces and Interfaces (Q1) - Physical and Theoretical Chemistry (Q1) - Medicine (miscellaneous) (Q1)
Financiación: info:eu-repo/grantAgreement/ES/DGA/Fondo Social DGA-grupos DGA
Financiación: info:eu-repo/grantAgreement/ES/MINECO-FEDER/MAT2016-78266-P
Financiación: info:eu-repo/grantAgreement/ES/MINECO/SAF2014-54763-C2-2-R
Tipo y forma: Article (PostPrint)
Área (Departamento): Área Química Orgánica (Dpto. Química Orgánica)
You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use. You may not use the material for commercial purposes. If you remix, transform, or build upon the material, you may not distribute the modified material. Exportado de SIDERAL (2019-12-12-10:03:49)
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Record created 2019-05-23, last modified 2019-12-12