RGD-Functionalized Fe3O4 nanoparticles for magnetic hyperthermia

Arriortua, O.K. ; Insausti, M. ; Lezama, L. ; Gil de Muro, I. ; Garaio, E. ; de la Fuente, J.M. (Universidad de Zaragoza) ; Fratila, R.M. ; Morales, M.P. ; Costa, R. ; Eceiza, M. ; Sagartzazu-Aizpurua, M. ; Aizpurua, J.M.

Resumen: To improve the selectivity of magnetic nanoparticles for tumor treatment by hyperthermia, Fe3O4 nanoparticles have been functionalized with a peptide of the type arginine-glycine-aspartate (RGD) following a “click” chemistry approach. The RGD peptide was linked onto the previously coated nanoparticles in order to target avß3 integrin receptors over-expressed in angiogenic cancer cells. Different coatings have been analyzed to enhance the biocompatibility of magnetic nanoparticles. Monodispersed and homogeneous magnetite nanoparticles have been synthesized by the seed growth method and have been characterized using X-ray diffraction, thermogravimetric analysis, infrared spectroscopy, transmission electron microscopy and magnetic measurements. The magnetic hyperthermia efficiency of the nanoparticles has also been investigated and cytotoxicity assays have been perfomed for functionalized nanoparticles.

Idioma: Inglés

DOI: 10.1016/j.colsurfb.2018.02.031

Año: 2018

Publicado en: COLLOIDS AND SURFACES B-BIOINTERFACES 165 (2018), 315-324
ISSN: 0927-7765

Factor impacto JCR: 3.973 (2018)

Categ. JCR: BIOPHYSICS rank: 15 / 72 = 0.208 (2018) - Q1 - T1
Categ. JCR: MATERIALS SCIENCE, BIOMATERIALS rank: 11 / 32 = 0.344 (2018) - Q2 - T2
Categ. JCR: CHEMISTRY, PHYSICAL rank: 49 / 148 = 0.331 (2018) - Q2 - T2

Factor impacto SCIMAGO: 0.957 - Biotechnology (Q1) - Colloid and Surface Chemistry (Q1) - Surfaces and Interfaces (Q1) - Physical and Theoretical Chemistry (Q1) - Medicine (miscellaneous) (Q1)

Financiación: info:eu-repo/grantAgreement/ES/DGA/Fondo Social DGA-grupos DGA
Financiación: info:eu-repo/grantAgreement/ES/MINECO-FEDER/MAT2016-78266-P
Financiación: info:eu-repo/grantAgreement/ES/MINECO/SAF2014-54763-C2-2-R

Tipo y forma: Article (PostPrint)

Área (Departamento): Área Química Orgánica (Dpto. Química Orgánica)