Food derived respiratory complex I inhibitors modify the effect of Leber hereditary optic neuropathy mutations
López-Gallardo, E. (Universidad de Zaragoza) ; Emperador, S. (Universidad de Zaragoza) ; Hernández-Ainsa, C. (Universidad de Zaragoza) ; Montoya, J. (Universidad de Zaragoza) ; Bayona-Bafaluy, M.P. (Universidad de Zaragoza) ; Ruiz-Pesini, E. (Universidad de Zaragoza)
Resumen: Mitochondrial DNA mutations in genes encoding respiratory complex I polypeptides can cause Leber hereditary optic neuropathy. Toxics affecting oxidative phosphorylation system can also cause mitochondrial optic neuropathy. Some complex I inhibitors found in edible plants might differentially interact with these pathologic mutations and modify their penetrance. To analyze this interaction, we have compared the effect of rotenone, capsaicin and rolliniastatin-1 on cybrids harboring the most frequent Leber hereditary optic neuropathy mutations and found that m.3460G > A mutation increases rotenone resistance but capsaicin and rolliniastatin-1 susceptibility. Thus, to explain the pathogenicity of mitochondrial diseases due to mitochondrial DNA mutations, their potential interactions with environment factors will have to be considered.
Idioma: Inglés
DOI: 10.1016/j.fct.2018.07.014
Año: 2018
Publicado en: FOOD AND CHEMICAL TOXICOLOGY 120 (2018), 89-97
ISSN: 0278-6915
Factor impacto JCR: 3.775 (2018)
Categ. JCR: TOXICOLOGY rank: 18 / 93 = 0.194 (2018) - Q1 - T1
Categ. JCR: FOOD SCIENCE & TECHNOLOGY rank: 21 / 135 = 0.156 (2018) - Q1 - T1
Factor impacto SCIMAGO: 0.916 - Food Science (Q1) - Toxicology (Q1) - Medicine (miscellaneous) (Q1)
Financiación: info:eu-repo/grantAgreement/ES/DGA-FEDER/B33-17R
Financiación: info:eu-repo/grantAgreement/ES/ISCIII/PI14-00070
Financiación: info:eu-repo/grantAgreement/ES/ISCIII/PI17-00021
Financiación: info:eu-repo/grantAgreement/ES/ISCIII/PI17-00166
Financiación: info:eu-repo/grantAgreement/ES/ISCIII/P114-00005
Tipo y forma: Article (PostPrint)
Área (Departamento): Area Histología (Dpto. Anatom.Histolog.Humanas)
Área (Departamento): Área Bioquímica y Biolog.Mole. (Dpto. Bioq.Biolog.Mol. Celular)
You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use. You may not use the material for commercial purposes. If you remix, transform, or build upon the material, you may not distribute the modified material.
Exportado de SIDERAL (2020-02-17-12:42:59)
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Idioma: Inglés
DOI: 10.1016/j.fct.2018.07.014
Año: 2018
Publicado en: FOOD AND CHEMICAL TOXICOLOGY 120 (2018), 89-97
ISSN: 0278-6915
Factor impacto JCR: 3.775 (2018)
Categ. JCR: TOXICOLOGY rank: 18 / 93 = 0.194 (2018) - Q1 - T1
Categ. JCR: FOOD SCIENCE & TECHNOLOGY rank: 21 / 135 = 0.156 (2018) - Q1 - T1
Factor impacto SCIMAGO: 0.916 - Food Science (Q1) - Toxicology (Q1) - Medicine (miscellaneous) (Q1)
Financiación: info:eu-repo/grantAgreement/ES/DGA-FEDER/B33-17R
Financiación: info:eu-repo/grantAgreement/ES/ISCIII/PI14-00070
Financiación: info:eu-repo/grantAgreement/ES/ISCIII/PI17-00021
Financiación: info:eu-repo/grantAgreement/ES/ISCIII/PI17-00166
Financiación: info:eu-repo/grantAgreement/ES/ISCIII/P114-00005
Tipo y forma: Article (PostPrint)
Área (Departamento): Area Histología (Dpto. Anatom.Histolog.Humanas)
Área (Departamento): Área Bioquímica y Biolog.Mole. (Dpto. Bioq.Biolog.Mol. Celular)
You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use. You may not use the material for commercial purposes. If you remix, transform, or build upon the material, you may not distribute the modified material. Exportado de SIDERAL (2020-02-17-12:42:59)
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Record created 2019-05-29, last modified 2020-02-17