Food derived respiratory complex I inhibitors modify the effect of Leber hereditary optic neuropathy mutations

López-Gallardo, E. (Universidad de Zaragoza) ; Emperador, S. (Universidad de Zaragoza) ; Hernández-Ainsa, C. (Universidad de Zaragoza) ; Montoya, J. (Universidad de Zaragoza) ; Bayona-Bafaluy, M.P. (Universidad de Zaragoza) ; Ruiz-Pesini, E. (Universidad de Zaragoza)

Resumen: Mitochondrial DNA mutations in genes encoding respiratory complex I polypeptides can cause Leber hereditary optic neuropathy. Toxics affecting oxidative phosphorylation system can also cause mitochondrial optic neuropathy. Some complex I inhibitors found in edible plants might differentially interact with these pathologic mutations and modify their penetrance. To analyze this interaction, we have compared the effect of rotenone, capsaicin and rolliniastatin-1 on cybrids harboring the most frequent Leber hereditary optic neuropathy mutations and found that m.3460G > A mutation increases rotenone resistance but capsaicin and rolliniastatin-1 susceptibility. Thus, to explain the pathogenicity of mitochondrial diseases due to mitochondrial DNA mutations, their potential interactions with environment factors will have to be considered.

Idioma: Inglés

DOI: 10.1016/j.fct.2018.07.014

Año: 2018

Publicado en: FOOD AND CHEMICAL TOXICOLOGY 120 (2018), 89-97
ISSN: 0278-6915

Factor impacto JCR: 3.775 (2018)

Categ. JCR: TOXICOLOGY rank: 18 / 93 = 0.194 (2018) - Q1 - T1
Categ. JCR: FOOD SCIENCE & TECHNOLOGY rank: 21 / 135 = 0.156 (2018) - Q1 - T1

Factor impacto SCIMAGO: 0.916 - Food Science (Q1) - Toxicology (Q1) - Medicine (miscellaneous) (Q1)

Financiación: info:eu-repo/grantAgreement/ES/DGA-FEDER/B33-17R
Financiación: info:eu-repo/grantAgreement/ES/ISCIII/PI14-00070
Financiación: info:eu-repo/grantAgreement/ES/ISCIII/PI17-00021
Financiación: info:eu-repo/grantAgreement/ES/ISCIII/PI17-00166
Financiación: info:eu-repo/grantAgreement/ES/ISCIII/P114-00005

Tipo y forma: Article (PostPrint)

Área (Departamento): Area Histología (Dpto. Anatom.Histolog.Humanas)
Área (Departamento): Área Bioquímica y Biolog.Mole. (Dpto. Bioq.Biolog.Mol. Celular)