Scrapie strain typing of brain and lymph node-derived isolates in ovinized models reveals mixture of substrains with distinct pathobiological properties

Barrio, T (Universidad de Zaragoza) ; Filali, H (Universidad de Zaragoza) ; Otero, A ; Sheleby-Elias, J ; Marin, B (Universidad de Zaragoza) ; Vidal, E ; Torres, J.M ; Groschup, M ; Andreoletti, O ; Badiola, J.J ; Bolea, R.

Resumen: Contrasting the knowledge about prion diseases or TSEs in sheep, only a very limited number of strain typing studies are available in goats. Two cases deriv- ing from the zoonotic bovine BSE epidemic were however detected in goats. During 2004–2012, over 70 TSE goat brain samples were collected from seven European countries and evaluated for TSE type/strain variation. A selection of these materials was chosen for in-depth analysis based on various criteria: tissue quality, genotype, broad geographical distribution, potential type variation....

Idioma: Inglés

DOI: 10.1080/19336896.2019.1615197

Año: 2019

Publicado en: Prion 13, Supp. 1 (2019), 33
ISSN: 1933-6896

Factor impacto JCR: 1.952 (2019)

Categ. JCR: BIOCHEMISTRY & MOLECULAR BIOLOGY rank: 233 / 297 = 0.785 (2019) - Q4 - T3

Factor impacto SCIMAGO: 0.593 - Biochemistry (Q3) - Infectious Diseases (Q3) - Cell Biology (Q3) - Cellular and Molecular Neuroscience (Q4)

Tipo y forma: Congress (Published version)

Área (Departamento): Área Sanidad Animal (Dpto. Patología Animal)