Mechano-sensing and cell migration: A 3D model approach
Resumen: Cell migration is essential for tissue development in different physiological and pathological conditions. It is a complex process orchestrated by chemistry, biological factors, microstructure and surrounding mechanical properties. Focusing on the mechanical interactions, cells do not only exert forces on the matrix that surrounds them, but they also sense and react to mechanical cues in a process called mechano-sensing. Here, we hypothesize the involvement of mechano-sensing in the regulation of directional cell migration through a three-dimensional (3D) matrix. For this purpose, we develop a 3D numerical model of individual cell migration, which incorporates the mechano-sensing process of the cell as the main mechanism regulating its movement. Consistent with this hypothesis, we found that factors, such as substrate stiffness, boundary conditions and external forces, regulate specific and distinct cell movements.
Idioma: Inglés
DOI: 10.1088/1478-3975/8/6/066008
Año: 2011
Publicado en: Physical Biology 8, 6 (2011), [13 pp.]
ISSN: 1478-3967

Factor impacto JCR: 2.595 (2011)
Categ. JCR: BIOPHYSICS rank: 36 / 74 = 0.486 (2011) - Q2 - T2
Financiación: info:eu-repo/grantAgreement/ES/MINECO/BES-2010-029927-FPI
Financiación: info:eu-repo/grantAgreement/ES/MINECO/DPI2009-14115-CO3-01
Tipo y forma: Artículo (Versión definitiva)
Área (Departamento): Área Mec.Med.Cont. y Teor.Est. (Dpto. Ingeniería Mecánica)

Derechos Reservados Derechos reservados por el editor de la revista

Exportado de SIDERAL (2019-10-25-15:00:07)

Este artículo se encuentra en las siguientes colecciones:

 Registro creado el 2019-10-25, última modificación el 2019-10-25

Versión publicada:
Valore este documento:

Rate this document:
(Sin ninguna reseña)