Social brain, social dysfunction and social withdrawal

Porcelli, S. ; Van Der Wee, N. ; van der Werff, S. ; Aghajani, M. ; Glennon, J.C. ; van Heukelum, S. ; Mogavero, F. ; Lobo, A. (Universidad de Zaragoza) ; Olivera, F.J. (Universidad de Zaragoza) ; Lobo, E. (Universidad de Zaragoza) ; Posadas, M. ; Dukart, J. ; Kozak, R. ; Arce, E. ; Ikram, A. ; Vorstman, J. ; Bilderbeck, A. ; Saris, I. ; Kas, M.J. ; Serretti, A.

Resumen: The human social brain is complex. Current knowledge fails to define the neurobiological processes underlying social behaviour involving the (patho-) physiological mechanisms that link system-level phenomena to the multiple hierarchies of brain function. Unfortunately, such a high complexity may also be associated with a high susceptibility to several pathogenic interventions. Consistently, social deficits sometimes represent the first signs of a number of neuropsychiatric disorders including schizophrenia (SCZ), Alzheimer''s disease (AD) and major depressive disorder (MDD) which leads to a progressive social dysfunction. In the present review we summarize present knowledge linking neurobiological substrates sustaining social functioning, social dysfunction and social withdrawal in major psychiatric disorders. Interestingly, AD, SCZ, and MDD affect the social brain in similar ways. Thus, social dysfunction and its most evident clinical expression (i.e., social withdrawal) may represent an innovative transdiagnostic domain, with the potential of being an independent entity in terms of biological roots, with the perspective of targeted interventions.

Idioma: Inglés

DOI: 10.1016/j.neubiorev.2018.09.012

Año: 2018

Publicado en: NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS 97 (2018), 10 - 33
ISSN: 0149-7634

Factor impacto JCR: 8.002 (2018)

Categ. JCR: NEUROSCIENCES rank: 18 / 266 = 0.068 (2018) - Q1 - T1
Categ. JCR: BEHAVIORAL SCIENCES rank: 3 / 53 = 0.057 (2018) - Q1 - T1

Factor impacto SCIMAGO: 3.734 - Behavioral Neuroscience (Q1) - Neuropsychology and Physiological Psychology (Q1) - Cognitive Neuroscience (Q1)

Financiación: info:eu-repo/grantAgreement/EC/H2020/115916/EU/Psychiatric Ratings using Intermediate Stratified Markers/PRISM

Tipo y forma: Artículo (PostPrint)

Área (Departamento): Area Anatom.Embriol.Humana (Dpto. Anatom.Histolog.Humanas)
Área (Departamento): Area Psiquiatría (Dpto. Medicina, Psiqu. y Derm.)
Área (Departamento): Área Medic.Prevent.Salud Públ. (Dpto. Microb.Med.Pr.,Sal.Públ.)