Relating constructs of attention and working memory to social withdrawal in Alzheimer's disease and schizophrenia: issues regarding paradigm selection

Gilmour, G. ; Porcelli, S. ; Bertaina-Anglade, V. ; Arce, E. ; Dukart, J. ; Hayen, A. ; Lobo, A. (Universidad de Zaragoza) ; Lopez-Anton, R. (Universidad de Zaragoza) ; Merlo Pich, E. ; Pemberton, D.J. ; Havenith, M.N. ; Glennon, J.C. ; Harel, B.T. ; Dawson, G. ; Marston, H. ; Kozak, R. ; Serretti, A.

Resumen: Central nervous system diseases are not currently diagnosed based on knowledge of biological mechanisms underlying their symptoms. Greater understanding may be offered through an agnostic approach to traditional disease categories, where learning more about shared biological mechanisms across conditions could potentially reclassify sub-groups of patients to allow realisation of more effective treatments. This review represents the output of the collaborative group “PRISM”, tasked with considering assay choices for assessment of attention and working memory in a transdiagnostic cohort of Alzheimer''s disease and schizophrenia patients exhibiting symptomatic spectra of social withdrawal. A multidimensional analysis of this nature has not been previously attempted. Nominated assays (continuous performance test III, attention network test, digit symbol substitution, N-back, complex span, spatial navigation in a virtual environment) reflected a necessary compromise between the need for broad assessment of the neuropsychological constructs in question with several pragmatic criteria: patient burden, compatibility with neurophysiologic measures and availability of preclinical homologues.

Idioma: Inglés

DOI: 10.1016/j.neubiorev.2018.09.025

Año: 2018

Publicado en: NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS 97 (2018), 47-69
ISSN: 0149-7634

Factor impacto JCR: 8.002 (2018)

Categ. JCR: NEUROSCIENCES rank: 18 / 266 = 0.068 (2018) - Q1 - T1
Categ. JCR: BEHAVIORAL SCIENCES rank: 3 / 53 = 0.057 (2018) - Q1 - T1

Factor impacto SCIMAGO: 3.734 - Behavioral Neuroscience (Q1) - Neuropsychology and Physiological Psychology (Q1) - Cognitive Neuroscience (Q1)

Financiación: info:eu-repo/grantAgreement/EC/H2020/115916/EU/Psychiatric Ratings using Intermediate Stratified Markers/PRISM

Tipo y forma: Artículo (PostPrint)

Área (Departamento): Área Psicología Básica (Dpto. Psicología y Sociología)
Área (Departamento): Area Anatom.Embriol.Humana (Dpto. Anatom.Histolog.Humanas)