Effects of attachment-based compassion therapy (ABCT) on brain-derived neurotrophic factor and low-grade inflammation among fibromyalgia patients: A randomized controlled trial

Montero-Marin, Jesús ; Andrés-Rodríguez, Laura ; Tops, Mattie ; Luciano, Juan V. ; Navarro-Gil, Mayte (Universidad de Zaragoza) ; Feliu-Soler, Albert ; López-del-Hoyo, Yolanda (Universidad de Zaragoza) ; Garcia-Campayo, Javier (Universidad de Zaragoza)

Resumen: Fibromyalgia (FM) is a disabling syndrome characterized by chronic pain associated with fatigue. Its pathogenesis is unknown, but alterations in central sensitization, involving an imbalance of brain-derived neurotrophic factor (BDNF) and inflammatory biomarkers, appear to be implicated. The aim of this study was to evaluate the impact of attachment-based compassion therapy (ABCT) on levels of BDNF, the inflammatory markers TNF-a, IL-6, IL-10, and the C-reactive protein (CRP), analysing whether biomarkers play a mediating/moderating role in improvements in FM functional status. Thirty-four female patients with FM participated in a RCT and were assigned to ABCT or relaxation therapy. Blood extractions were conducted at baseline and post-intervention, with self-report assessments of functional status (FIQ) at baseline, post-intervention and 3-month follow-up. A pro-inflammatory composite was obtained by summing up IL-6, TNF-a and CRP normalized values. Non-parametric tests, analysis of variance and regression models were used to evaluate treatment and mediation/moderation. Compared to relaxation therapy, ABCT showed significant improvements in FIQ and decreases in BDNF, CRP, and pro-inflammatory composite. Changes in BDNF had a mediating role in FIQ. ABCT seems to reduce BDNF and appears to have anti-inflammatory effects in FM patients. Reductions in BDNF could be a mechanism of FM functional status improvement.

Idioma: Inglés

DOI: 10.1038/s41598-019-52260-z

Año: 2019

Publicado en: Scientific Reports 9, 1 (2019), 15639 [14 pp.]
ISSN: 2045-2322

Originalmente disponible en: Texto completo de la revista

Factor impacto JCR: 3.998 (2019)

Categ. JCR: MULTIDISCIPLINARY SCIENCES rank: 17 / 71 = 0.239 (2019) - Q1 - T1

Factor impacto SCIMAGO: 1.341 - Multidisciplinary (Q1)

Financiación: info:eu-repo/grantAgreement/ES/DGA/B17-17R
Financiación: info:eu-repo/grantAgreement/ES/ISCIII/CD16-00147
Financiación: info:eu-repo/grantAgreement/ES/ISCIII-MINECO-FEDER/RD16-0007-0005
Financiación: info:eu-repo/grantAgreement/ES/ISCIII/RD16-0007-0012
Financiación: info:eu-repo/grantAgreement/ES/MICINN/ISCIII-RD06-0018-0017

Tipo y forma: Article (Published version)

Área (Departamento): Área Psicología Básica (Dpto. Psicología y Sociología)
Área (Departamento): Area Psiquiatría (Dpto. Medicina, Psiqu. y Derm.)
Área (Departamento): Área Psicolog.Evolut.Educac (Dpto. Psicología y Sociología)