ANGPTL-4 is associated with obesity and lipid profile in children and adolescents

Barja-Fernández S. ; Folgueira C. ; Castelao C. ; Pena-León V. ; González-Saenz P. ; Vázquez-Cobela R. ; Aguilera C.M. ; Gil-Campos M. ; Bueno G. (Universidad de Zaragoza) ; Gil Á. ; Moreno L.A. (Universidad de Zaragoza) ; Ruiz-Piñon M. ; García-Palacios M. ; Casanueva F.F. ; Diéguez C. ; Nogueiras R. ; Leis R. ; Seoane L.M.

Resumen: Angiopoietin-like protein 4 (ANGPTL-4) regulates lipidic metabolism and a_ects energy homeostasis. However, its function in children with obesity remains unknown. We investigated plasma ANGPTL-4 levels in children and its relationship with body mass index (BMI) and di_erent lipidic parameters such as free fatty acids (FFA). Plasma ANGPTL-4 levels were analyzed in two di_erent cohorts. In the first cohort (n = 150, age 3-17 years), which included children with normal weight or obesity, we performed a cross-sectional study. In the second cohort, which included only children with obesity (n = 20, age 5-18 years) followed up for two years after an intervention for weight loss, in which we performed a longitudinal study measuring ANGPTL-4 before and after BMI-loss. In the cross-sectional study, circulating ANGPTL-4 levels were lower in children with obesity than in those with normal weight. Moreover, ANGPTL-4 presented a negative correlation with BMI, waist circumference, weight, insulin, homeostasis model assessment of insulin resistance index (HOMA index), triglycerides, and leptin, and a positive correlation with FFA and vitamin-D. In the longitudinal study, the percent change in plasma ANGPTL-4 was correlated with the percent change in FFA, total-cholesterol and high-density lipoprotein cholesterol. This study reveals a significant association of ANGPTL-4 with pediatric obesity and plasma lipid profile.

Idioma: Inglés

DOI: 10.3390/nu11061340

Año: 2019

Publicado en: NUTRIENTS 11, 6 (2019), 1340 [14 pp.]
ISSN: 2072-6643

Factor impacto JCR: 4.546 (2019)

Categ. JCR: NUTRITION & DIETETICS rank: 17 / 89 = 0.191 (2019) - Q1 - T1

Factor impacto SCIMAGO: 1.329 - Nutrition and Dietetics (Q1) - Food Science (Q1)

Financiación: info:eu-repo/grantAgreement/ES/ISCIII/PI11-02042
Financiación: info:eu-repo/grantAgreement/ES/ISCIII/PI15-01272
Financiación: info:eu-repo/grantAgreement/ES/ISCIII/PI16-00871
Financiación: info:eu-repo/grantAgreement/ES/ISCIII/PI16-01301
Financiación: info:eu-repo/grantAgreement/ES/ISCIII/PI18-00998

Tipo y forma: Article (Published version)

Área (Departamento): Área Enfermería (Dpto. Fisiatría y Enfermería)
Área (Departamento): Área Pediatría (Dpto. Pediatría Radiol.Med.Fís)