Rev1 wbdR tagged vaccines against Brucella ovis
Aragón-Aranda, Beatriz ; De Miguel, María Jesús ; Martínez-Gómez, Estrella ; Zúñiga-Ripa, Amaia ; Salvador-Bescós, Miriam ; Moriyón, Ignacio ; Iriarte, Maite ; Muñoz, Pilar M. ; Conde-Álvarez, Raquel
Resumen: Sheep brucellosis is a worldwide extended disease caused by B. melitensis and B. ovis, two species respectively carrying smooth or rough lipopolysaccharide. Vaccine B. melitensis Rev1 is used against B. melitensis and B. ovis but induces an anti-smooth-lipopolysaccharide response interfering with B. melitensis serodiagnosis, which precludes its use against B. ovis where B. melitensis is absent. In mice, Rev1 deleted in wbkC (Brucella lipopolysaccharide formyl-transferase) and carrying wbdR (E. coli acetyl-transferase) triggered antibodies that could be differentiated from those evoked by wild-type strains, was comparatively attenuated and protected against B. ovis, suggesting its potential as a B. ovis vaccine.
Idioma: Inglés
DOI: 10.1186/s13567-019-0714-3
Año: 2019
Publicado en: Veterinary Research 50 (2019), 95 [9 pp.]
ISSN: 0928-4249
Factor impacto JCR: 3.357 (2019)
Categ. JCR: VETERINARY SCIENCES rank: 6 / 142 = 0.042 (2019) - Q1 - T1
Factor impacto SCIMAGO: 1.425 - Veterinary (miscellaneous) (Q1)
Financiación: info:eu-repo/grantAgreement/ES/MINECO/AGL2014-58795-C4-1-R
Financiación: info:eu-repo/grantAgreement/ES/MINECO/BES-2015-075609
Tipo y forma: Article (Published version)
You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
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Idioma: Inglés
DOI: 10.1186/s13567-019-0714-3
Año: 2019
Publicado en: Veterinary Research 50 (2019), 95 [9 pp.]
ISSN: 0928-4249
Factor impacto JCR: 3.357 (2019)
Categ. JCR: VETERINARY SCIENCES rank: 6 / 142 = 0.042 (2019) - Q1 - T1
Factor impacto SCIMAGO: 1.425 - Veterinary (miscellaneous) (Q1)
Financiación: info:eu-repo/grantAgreement/ES/MINECO/AGL2014-58795-C4-1-R
Financiación: info:eu-repo/grantAgreement/ES/MINECO/BES-2015-075609
Tipo y forma: Article (Published version)
You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use. Exportado de SIDERAL (2020-07-16-09:46:10)
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Record created 2020-02-04, last modified 2020-07-16