Surfactant-free synthesis and scalable purification of triangular gold nanoprisms with low non-specific cellular uptake

Ramírez Jiménez, Rafael ; Artiga, Álvaro ; Mitchell, Scott G. (Universidad de Zaragoza) ; Martín Rapún, Rafael (Universidad de Zaragoza) ; de la Fuente, Jesús M.

Resumen: Gold nanoprisms possess remarkable optical properties that make them useful for medical biotechnology applications such as diagnosis and photothermal therapy. However, shape-selective synthesis of gold nanoprisms is not trivial and typically requires either toxic surfactants or time-consuming purification protocols, which can limit their applicability. Here, we show how triangular gold nanoprisms of different sizes can be purified by precipitation using the non-toxic glutathione ligand, thereby removing the need for toxic surfactants and bottleneck purification techniques. The protocol is amenable for direct scaling up as no instrumentation is required in the critical purification step. The new purification method provides a two-fold increased yield in gold nanoprisms compared to electrophoretic filtration, while providing nanoprisms of similar localized surface plasmon resonance wavelength. Crucially, the gold nanoprisms isolated using this methodology show fewer non-specific interactions with cells and lower cellular internalization, which paves the way for a higher selectivity in therapeutic applications.

Idioma: Inglés

DOI: 10.3390/nano10030539

Año: 2020

Publicado en: Nanomaterials 10, 3 (2020), 539 [10 pp.]
ISSN: 2079-4991

Factor impacto JCR: 5.076 (2020)

Categ. JCR: PHYSICS, APPLIED rank: 35 / 160 = 0.219 (2020) - Q1 - T1
Categ. JCR: NANOSCIENCE & NANOTECHNOLOGY rank: 51 / 106 = 0.481 (2020) - Q2 - T2
Categ. JCR: CHEMISTRY, MULTIDISCIPLINARY rank: 55 / 178 = 0.309 (2020) - Q2 - T1
Categ. JCR: MATERIALS SCIENCE, MULTIDISCIPLINARY rank: 103 / 333 = 0.309 (2020) - Q2 - T1

Factor impacto SCIMAGO: 0.919 - Materials Science (miscellaneous) (Q1) - Chemical Engineering (miscellaneous) (Q1)

Financiación: info:eu-repo/grantAgreement/ES/MEC/FPU014-06249
Financiación: info:eu-repo/grantAgreement/ES/MINECO/BIO2017-84246-C2-1-R
Financiación: info:eu-repo/grantAgreement/ES/MINECO/RYC-2013-12570

Tipo y forma: Artículo (Versión definitiva)

Área (Departamento): Área Química Orgánica (Dpto. Química Orgánica)