Changes in total and inner retinal thicknesses in type 1 diabetes with no retinopathy after 8 years of follow-up

Pinilla Lozano, Maria Isabel (Universidad de Zaragoza) ; Idoipe Corta, Miriam (Universidad de Zaragoza) ; Perdices Royo, Lorena ; Sanchez Cano, Ana Isabel (Universidad de Zaragoza) ; Acha Perez, Javier (Universidad de Zaragoza) ; Lopez Galvez, Maria Isabel ; Orduna Hospital, Elvira (Universidad de Zaragoza)

Resumen: Purpose:To evaluate changes in retinal layer thickness in patients with Type 1 diabetes with no diabetic retinopathy after 8 years of follow-up.
Methods:Ninety Type 1 diabetes and 60 control eyes were studied. Changes in the retinal nerve fiber layer, ganglion cell layer, and inner nuclear layer thicknesses in all Early Treatment Diabetic Retinopathy Study areas were evaluated.
Results:The mean ages were 42.93 ± 13.62 and 41.52 ± 13.05 years in the diabetic and control group, respectively. In 2009, total retinal thickness was higher in diabetic patients; differences were statistically significant in all except the nasal areas. In both groups, the mean foveal thickness remained the same during the 8 years. Among diabetic patients, there was a significant reduction in total retinal thickness in all areas excluding the outer temporal one; controls only in the inferior areas. The thickness loss was due to the thinning of the inner retinal layers (inner nuclear layer, ganglion cell layer, and retinal nerve fiber layer). The controls showed a significant diminution in the retinal nerve fiber layer and in the ganglion cell layer areas. The inner nuclear layer showed a diminution in the diabetes mellitus group.
Conclusion:Before the onset of diabetic retinopathy, Type 1 diabetes patients experience a diminution of their inner retinal layer thicknesses over time, supporting the hypothesis of retinal neurodegeneration.

Idioma: Inglés

DOI: 10.1097/IAE.0000000000002576

Año: 2020

Publicado en: RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES 40, 7 (2020), 1379 - 1386
ISSN: 0275-004X

Factor impacto JCR: 4.256 (2020)

Categ. JCR: OPHTHALMOLOGY rank: 10 / 62 = 0.161 (2020) - Q1 - T1

Factor impacto SCIMAGO: 2.24 - Ophthalmology (Q1) - Medicine (miscellaneous) (Q1)

Tipo y forma: Article (PostPrint)

Área (Departamento): Area Medicina (Dpto. Medicina, Psiqu. y Derm.)
Área (Departamento): Área Oftalmología (Dpto. Cirugía)
Área (Departamento): Área Óptica (Dpto. Física Aplicada)